Emerging biomedical applications of synthetic biology

被引：236
作者：
Weber, Wilfried [3 ,4 ]
Fussenegger, Martin [1 ,2 ]
机构：
[1] Swiss Fed Inst Technol, Dept Biosyst Sci & Engn, CH-4058 Basel, Switzerland
[2] Univ Basel, Fac Sci, CH-4058 Basel, Switzerland
[3] Univ Freiburg, Fac Biol, D-79104 Freiburg, Germany
[4] Univ Freiburg, BIOSS Ctr Biol Signalling Studies, D-79104 Freiburg, Germany
来源：
NATURE REVIEWS GENETICS | 2012年 / 13卷 / 01期
基金：
瑞士国家科学基金会; 欧洲研究理事会;
关键词：
ENGINEERING ESCHERICHIA-COLI; GENE-REGULATION SYSTEMS; MAMMALIAN-CELLS; TOGGLE SWITCH; CANCER-CELLS; TRANSCRIPTIONAL REGULATORS; TRANSGENE EXPRESSION; PROTEIN TRANSDUCTION; INDUCIBLE RELEASE; DRUG DISCOVERY;
D O I：
10.1038/nrg3094
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Synthetic biology aims to create functional devices, systems and organisms with novel and useful functions on the basis of catalogued and standardized biological building blocks. Although they were initially constructed to elucidate the dynamics of simple processes, designed devices now contribute to the understanding of disease mechanisms, provide novel diagnostic tools, enable economic production of therapeutics and allow the design of novel strategies for the treatment of cancer, immune diseases and metabolic disorders, such as diabetes and gout, as well as a range of infectious diseases. In this Review, we cover the impact and potential of synthetic biology for biomedical applications.
引用
收藏
页码：21 / 35
页数：15
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