Selective Hydroboration-Oxidation of Terminal Alkenes under Flow Conditions

被引：8

作者：

Elsherbini, Mohamed ^{[1
]}

Huynh, Florence ^{[1
]}

Dunbabin, Alice ^{[1
]}

Allemann, Rudolf K. ^{[1
]}

Wirth, Thomas ^{[1
]}

机构：

[1] Cardiff Univ, Sch Chem, Main Bldg,Pk Pl, Cardiff CF10 3AT, Wales

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2020年 / 26卷 / 50期

基金：

英国生物技术与生命科学研究理事会;

关键词：

alcohols; alkenes; flow chemistry; hydroboration; oxidation; BORANE;

D O I：

10.1002/chem.202001650

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient flow process for the selective hydroboration and oxidation of different alkenes using 9-borabicyclo(3.3.1)nonane (9-BBN) allows facile conversion in high productivity (1.4 g h(-1)) of amorpha-4,11-diene to the corresponding alcohol, which is an advanced intermediate in the synthesis of the antimalarial drug artemisinin. The in situ reaction of borane and 1,5-cyclooctadiene using a simple flow generator proved to be a cost efficient solution for the generation of 9-BBN.

引用

页码：11423 / 11425

页数：3

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