Gp2.5, the multifunctional bacteriophage T7 single-stranded DNA binding protein

被引：28
作者：
Hernandez, Alfredo J. [1 ]
Richardson, Charles C. [1 ]
机构：
[1] Harvard Med Sch, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA
来源：
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2019年 / 86卷
关键词：
Bacteriophage T7; Single-stranded DNA binding protein; DNA replication annealing; Homologous; Recombination; GENE; 2.5; PROTEIN; CARBOXYL-TERMINAL DOMAIN; IN-VITRO REPAIR; ESCHERICHIA-COLI; DEOXYRIBONUCLEIC-ACID; CRYSTAL-STRUCTURE; HELICASE-PRIMASE; REPLICATION FORK; PRIMARY ORIGIN; NUCLEOTIDE-SEQUENCE;
D O I：
10.1016/j.semcdb.2018.03.018
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The essential bacteriophage T7-encoded single-stranded DNA binding protein is the nexus of T7 DNA metabolism. Multiple layers of macromolecular interactions mediate its function in replication, recombination, repair, and the maturation of viral genomes. In addition to binding ssDNA, the protein binds to DNA polymerase and DNA helicase, regulating their activities. The protein displays potent homologous DNA annealing activity, underscoring its role in recombination. (C) 2018 Elsevier Ltd. All rights reserved.
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收藏
页码：92 / 101
页数：10
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