Zika virus: what, where from and where to?

被引：20

作者：

Basile, Kerri ^{[1
,2
,3
]}

Kok, Jen ^{[1
,2
,3
]}

Dwyer, Dominic E. ^{[1
,2
,3
]}

机构：

[1] Univ Sydney, Ctr Infect Dis & Microbiol Lab Serv, Inst Clin Pathol & Med Res, NSW Hlth Pathol,Westmead Hosp, Westmead, NSW, Australia

[2] Univ Sydney, Marie Bashir Inst Infect Dis & Biosecur, Westmead Hosp, Westmead, NSW, Australia

[3] Univ Sydney, Ctr Res Excellence Crit Infect, Westmead Hosp, Westmead, NSW, Australia

来源：

PATHOLOGY | 2017年 / 49卷 / 07期

关键词：

Zika virus; flavivirus; Aedes; microcephaly; Guillain-Barre syndrome; MALE SEXUAL TRANSMISSION; DENGUE VIRUS; GENOMIC CHARACTERIZATION; FRENCH-POLYNESIA; INFECTION; BRAZIL; ENHANCEMENT; AMERICA; INHIBITORS; TRAVELERS;

D O I：

10.1016/j.pathol.2017.08.002

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

The significance of Zika virus as a clinically significant flavivirus has previously been under-recognised, until extensive outbreaks in Yap in 2007, French Polynesia in 2013 and the Americas since 2015. Although Zika virus infection is commonly asymptomatic or mild, emerging evidence suggests a strong link to microcephaly in babies and Guillain-Barre syndrome in adults. This article reviews the epidemiology, geographic distribution, basic virology, transmission, clinical presentation, potential complications, laboratory diagnosis, treatment and prevention of Zika virus infection. Education on mosquito avoidance measures and vector control efforts currently remain key to reducing risk of transmission, whilst further research is underway to develop antiviral therapies and vaccines.

引用

页码：698 / 706

页数：9

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