Interdisciplinary Management of Perianal Crohn's Disease

被引：8

作者：

Lightner, Amy L. ^{[1
]}

Faubion, William A. ^{[2
]}

Fletcher, Joel G. ^{[3
]}

机构：

[1] Mayo Clin, Div Colon & Rectal Surg, 200 1st St Southwest, Rochester, MN 55905 USA

[2] Mayo Clin, Div Gastroenterol, 200 1st St Southwest, Rochester, MN 55905 USA

[3] Mayo Clin, Div Radiol, 200 1st St Southwest, Rochester, MN 55905 USA

来源：

GASTROENTEROLOGY CLINICS OF NORTH AMERICA | 2017年 / 46卷 / 03期

关键词：

Perianal fistulizing disease; Crohn's disease; Combined medical and surgical management; FISTULA-IN-ANO; ENDORECTAL ADVANCEMENT FLAP; COMPLEX ANAL FISTULAS; QUALITY-OF-LIFE; SURGICAL-TREATMENT; ANORECTAL FISTULAS; CLINICAL-TRIAL; DOUBLE-BLIND; DEFINITIVE SURGERY; MYOCUTANEOUS FLAPS;

D O I：

10.1016/j.gtc.2017.05.008

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Perianal disease is a common manifestation of Crohn's disease (CD) that results in significant morbidity and decreased quality of life. Despite several medical and surgical options, complex perianal CD remains difficult to treat. Before the advent of biologic therapy, antibiotics were the mainstay of medical treatment. Infliximab remains the most well-studied medical therapy for perianal disease. Surgical interventions are limited by the risk of nonhealing wounds and potential incontinence. When treatment options fail, fecal diversion or proctectomy may be necessary. Stem cell therapies may offer improved results and seem to be safe, but are not yet widely used.

引用

页码：547 / +

页数：18

共 76 条

[1] AUTOLOGOUS FIBRIN GLUE IN THE TREATMENT OF RECTOVAGINAL AND COMPLEX FISTULAS [J].

ABEL, ME ;

CHIU, YSY ;

RUSSELL, TR ;

VOLPE, PA .

DISEASES OF THE COLON & RECTUM, 1993, 36 (05) :447-449

[2]

[Anonymous], GASTROENTEROL RES PR

[3] Prospective evaluation of dynamic contrast enhanced magnetic resonance imaging in the evaluation of fistula in ano [J].

Beckingham, IJ ;

Spencer, JA ;

Ward, J ;

Dyke, GW ;

Adams, C ;

Ambrose, NS .

BRITISH JOURNAL OF SURGERY, 1996, 83 (10) :1396-1398

[4] Preoperative MR imaging of anal fistulas: Does it really help the surgeon? [J].

Beets-Tan, RGH ;

Beets, GL ;

van der Hoop, AG ;

Kessels, AFH ;

Vliegen, RFA ;

Baeten, CGMI ;

van Engelshoven, JMA .

RADIOLOGY, 2001, 218 (01) :75-84

[5] The clinical course of fistulating Crohn's disease [J].

Bell, SJ ;

Williams, AB ;

Wiesel, P ;

Wilkinson, K ;

Cohen, RCG ;

Kamm, MA .

ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2003, 17 (09) :1145-1151

[6] Clinical examination, endosonography, and MR imaging in preoperative assessment of fistula in ano: Comparison with outcome-based reference standard [J].

Buchanan, GN ;

Halligan, S ;

Bartram, CI ;

Williams, AB ;

Tarroni, D ;

Cohen, CRG .

RADIOLOGY, 2004, 233 (03) :674-681

[7] Myocutaneous flaps promote perineal healing in inflammatory bowel disease [J].

Collie, MHS ;

Potter, MA ;

Bartolo, DCC .

BRITISH JOURNAL OF SURGERY, 2005, 92 (06) :740-741

[8] Adalimumab for the treatment of fistulas in patients with Crohn's disease [J].

Colombel, J-F ;

Schwartz, D. A. ;

Sandborn, W. J. ;

Kamm, M. A. ;

D'Haens, G. ;

Rutgeerts, P. ;

Enns, R. ;

Panaccione, R. ;

Schreiber, S. ;

Li, J. ;

Kent, J. D. ;

Lomax, K. G. ;

Pollack, P. F. .

GUT, 2009, 58 (07) :940-948

[9] Adalimumab combined with ciprofloxacin is superior to adalimumab monotherapy in perianal fistula closure in Crohn's disease: a randomised, double-blind, placebo controlled trial (ADAFI) [J].

Dewint, Pieter ;

Hansen, Bettina E. ;

Verhey, Elke ;

Oldenburg, Bas ;

Hommes, Daniel W. ;

Pierik, Marieke ;

Ponsioen, Cyriel I. J. ;

van Dullemen, Hendrik M. ;

Russel, Maurice ;

van Bodegraven, Ad A. ;

van der Woude, C. Janneke .

GUT, 2014, 63 (02) :292-299

[10] Long-term seton drainage for high anal fistulas in Crohn's disease - A sphincter-saving operation? [J].

Faucheron, JL ;

SaintMarc, O ;

Guibert, L ;

Parc, R .

DISEASES OF THE COLON & RECTUM, 1996, 39 (02) :208-211

← 1 2 3 4 5 6 7 8 →