TRAIL induces apoptosis and activation of NFκB

被引：0
作者：
Jeremias, I
Debatin, KM
机构：
[1] Univ Ulm, Kinderklin, D-89075 Ulm, Germany
[2] Deutsch Krebsforschungszentrum, D-60120 Heidelberg, Germany
来源：
EUROPEAN CYTOKINE NETWORK | 1998年 / 9卷 / 04期
关键词：
TRAIL; NF kappa B; apoptosis; resistance; lymphocytes;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
(TNF-related-apoptosis-inducing-ligand) mas found as a new member of the TNF family which mediates cell death in a wide variety of malignant cell lines and primary tumor cells. TRAIL induces two different signals, cell death mediated by caspases and gene induction mediated by NF kappa B. Inhibition of TRAIL-induced activation of NF kappa B augments apoptosis induction by TRAIL and attenuates apoptosis resistance.
引用
收藏
页码：687 / 688
页数：2
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