Codelivery of salinomycin and doxorubicin using nanoliposomes for targeting both liver cancer cells and cancer stem cells

被引：42

作者：

Gong, Zhirong ^{[1
]}

Chen, Dazhong ^{[1
]}

Xie, Fangyuan ^{[1
]}

Liu, Junjie ^{[1
]}

Zhang, He ^{[1
]}

Zou, Hao ^{[1
]}

Yu, Yuan ^{[1
]}

Chen, Yan ^{[1
]}

Sun, Zhiguo ^{[1
]}

Wang, Xinxia ^{[2
]}

Zhang, Hai ^{[2
]}

Zhang, Guoqing ^{[2
]}

Yin, Chuan ^{[3
]}

Gao, Jie ^{[1
]}

Zhong, Yanqiang ^{[1
]}

Lu, Ying ^{[1
]}

机构：

[1] Second Mil Med Univ, Dept Pharmaceut Sci, 325 Guohe Rd, Shanghai 200433, Peoples R China

[2] East Hosp Hepatobiliary Surg, Dept Pharm, 225 Changhai Rd, Shanghai 200433, Peoples R China

[3] Second Mil Med Univ, Changzheng Hosp, Dept Gastroenterol, Shanghai 200003, Peoples R China

来源：

NANOMEDICINE | 2016年 / 11卷 / 19期

基金：

中国国家自然科学基金;

关键词：

cancer stem cells; combined therapy; doxorubicin; liver cancer; nanoliposomes; salinomycin; BREAST-CANCER; HEPATOCELLULAR-CARCINOMA; COMBINATION THERAPY; DELIVERY; IMMUNOLIPOSOMES; NANOMEDICINE; ANTIBODY; DAUNORUBICIN; EQUILIBRIUM; POPULATIONS;

D O I：

10.2217/nnm-2016-0137

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Aim: To develop salinomycin-loaded nanoliposomes (SLN), doxorubicin-loaded nanoliposomes (DLN) and nanoliposomes codelivering salinomycin and doxorubicin (SDLN) to target both liver cancer cells and cancer stem cells. Materials & methods: The characterization and antitumor activity of SLN, DLN and SDLN were evaluated. Results & conclusion: The doxorubicin/salinomycin sodium mole ratio of 1: 1 had the best synergistic combination index value, and was chosen as the drug ratio in SDLN. SDLN could maintain the drug ratio between 1: 1 and 3: 1 in 12 h in vivo. SDLN and SLN + DLN showed the best tumor inhibitory rate, and could significantly decrease the percentage of liver cancer stem cells in vivo. SDLN and SLN + DLN may serve as an effective approach to treat liver cancer.

引用

页码：2565 / 2580

页数：16

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