Discriminative value of CA-125, HE4, Risk of Malignancy Index II (RMI-II) and Risk of Malignancy Algorithm (ROMA) in the differential diagnosis of pelvic masses: conclusions from a referral Centre in Portugal

被引：10
|
作者：
Melo, Angela [1 ]
Verissimo, Renata [1 ]
Farinha, Margarida [2 ]
Martins, Nuno Nogueira [1 ]
Martins, Francisco Nogueira [1 ]
机构：
[1] EPE, Ctr Hosp Tondela Viseu, Gynaecol & Obstet Dept, Ave Rei Dom Duarte, P-3504509 Viseu, Portugal
[2] EPE, Ctr Hosp Tondela Viseu, Lab Med Dept, Viseu, Portugal
来源：
JOURNAL OF OBSTETRICS AND GYNAECOLOGY | 2018年 / 38卷 / 08期
关键词：
Risk of Malignancy Algorithm (ROMA); Cancer Antigen 125 (CA-125); Human Epididymal Protein 4 (HE-4); Risk of Malignancy Index-II (RMI-II); serum biomarkers; ultrasound; EPITHELIAL OVARIAN-CANCER; PREOPERATIVE DIAGNOSIS; MENOPAUSAL STATUS; PROTEIN; 4; CA125; ULTRASOUND;
D O I：
10.1080/01443615.2018.1457632
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
The major purpose of this article was to compare the discriminative value of different algorithms and serum biomarkers in the differential diagnosis of adnexal masses. We performed a retrospective study with 247 women with adnexal neoplasia, submitted to surgical treatment and with a histological diagnosis. The evaluation of the area under the curve (AUC) for isolated CA-125 and HE4, and for ROMA and RMI-II, showed a better specificity of HE4 and RMI-II in premenopausal women. In the postmenopausal group, ROMA and RMI-II were the algorithms with a better performance.
引用
收藏
页码：1140 / 1145
页数：6
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