Measurement of motor disability in MPTP-treated macaques using a telemetry system for estimating circadian motor activity

被引：14

作者：

Barcia, C ^{[1
]}

De Pablos, V ^{[1
]}

Bautista-Hernández, V ^{[1
]}

Sanchez-Bahillo, A ^{[1
]}

Fernández-Barreiro, A ^{[1
]}

Poza, M ^{[1
]}

Herrero, MT ^{[1
]}

机构：

[1] Univ Murcia, Sch Med, Dept Human Anat & Psychol, Murcia 30071, Spain

来源：

JOURNAL OF NEUROSCIENCE METHODS | 2004年 / 134卷 / 01期

关键词：

parkinsonian syndrome; MPTP; macaques; motor activity; circadian rhythms;

D O I：

10.1016/j.jneumeth.2003.10.017

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The parkinsonian symptoms of primates after MPTP exposure can be measured by several visual methods (classical motor scores). However, these methods have a subjective bias, especially as regards the evaluation of the motor activity. Computerized monitoring systems represent an unbiased method for measuring the motor disability of monkeys after MPTP administration. In this work the motor activity of monkeys before and after MPTP administration is measured and compared with the activity of a control intact group by means of a telemetry system. A pronounced decrease in motor activity was observed after MPTP administration. These results suggest the monitoring method used is suited for characterizing the motor incapacity and possible improvements following treatments to test different therapies to control Parkinson's disease in MPTP models involving primates. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：59 / 64

页数：6

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