Obesity and the brain: how convincing is the addiction model?

被引:293
作者
Ziauddeen, Hisham [1 ,2 ,3 ]
Farooqi, I. Sadaf [3 ]
Fletcher, Paul C. [1 ,2 ]
机构
[1] Univ Cambridge, Addenbrookes Hosp, Dept Psychiat, Cambridge CB2 0SZ, England
[2] Cambridgeshire Peterborough NHS Fdn Trust Fulbour, Cambridge CB21 5EF, England
[3] Univ Cambridge, Metab Res Labs, Inst Metab Sci, Addenbrookes Hosp, Cambridge CB2 0QQ, England
基金
英国惠康基金;
关键词
DORSOLATERAL PREFRONTAL CORTEX; GENE TAQ1A POLYMORPHISM; DOPAMINE-RECEPTOR GENE; FOOD ADDICTION; DORSAL STRIATUM; ACCUMBENS DOPAMINE; EATING BEHAVIORS; LESS ACTIVATION; D2; RECEPTORS; NEURAL BASIS;
D O I
10.1038/nrn3212
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
An increasingly influential perspective conceptualizes both obesity and overeating as a food addiction accompanied by corresponding brain changes. Because there are far-reaching implications for clinical practice and social policy if it becomes widely accepted, a critical evaluation of this model is important. We examine the current evidence for the link between addiction and obesity, identifying several fundamental shortcomings in the model, as well as weaknesses and inconsistencies in the empirical support for it from human neuroscientific research.
引用
收藏
页码:279 / 286
页数:8
相关论文
共 101 条
  • [1] Neurobiological evidence for hedonic allostasis associated with escalating cocaine use
    Ahmed S.H.
    Kenny P.J.
    Koob G.F.
    Markou A.
    [J]. Nature Neuroscience, 2002, 5 (7) : 625 - 626
  • [2] [Anonymous], 2000, DIAGN STAT MAN MENT, DOI DOI 10.1176/APPI.BOOKS.9780890425787
  • [3] Sucrose sham feeding on a binge schedule releases accumbens dopamine repeatedly and eliminates the acetylcholine satiety response
    Avena, N. M.
    Rada, P.
    Moise, N.
    Hoebel, B. G.
    [J]. NEUROSCIENCE, 2006, 139 (03) : 813 - 820
  • [4] Evidence for sugar addiction: Behavioral and neurochemical effects of intermittent, excessive sugar intake
    Avena, Nicole M.
    Rada, Pedro
    Hoebel, Bartley G.
    [J]. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2008, 32 (01) : 20 - 39
  • [5] Sugar and Fat Bingeing Have Notable Differences in Addictive-like Behavior
    Avena, Nicole M.
    Rada, Pedro
    Hoebel, Bartley G.
    [J]. JOURNAL OF NUTRITION, 2009, 139 (03) : 623 - 628
  • [6] Sugar-dependent rats show enhanced responding for sugar after abstinence: Evidence of a sugar deprivation effect
    Avena, NM
    Long, KA
    Hoebel, BG
    [J]. PHYSIOLOGY & BEHAVIOR, 2005, 84 (03) : 359 - 362
  • [7] Body mass correlates inversely with inhibitory control in response to food among adolescent girls: An fMRI study
    Batterink, Laura
    Yokum, Sonja
    Stice, Eric
    [J]. NEUROIMAGE, 2010, 52 (04) : 1696 - 1703
  • [8] The plausibility of sugar addiction and its role in obesity and eating disorders
    Benton, David
    [J]. CLINICAL NUTRITION, 2010, 29 (03) : 288 - 303
  • [9] Rats that binge eat fat-rich food do not show somatic signs or anxiety associated with opiate-like withdrawal: Implications for nutrient-specific food addiction behaviors
    Bocarsly, Miriam E.
    Berner, Laura A.
    Hoebel, Bartley G.
    Avena, Nicole M.
    [J]. PHYSIOLOGY & BEHAVIOR, 2011, 104 (05) : 865 - 872
  • [10] Reward Abnormalities among Women with Full and Subthreshold Bulimia Nervosa: A Functional Magnetic Resonance Imaging Study
    Bohon, Cara
    Stice, Eric
    [J]. INTERNATIONAL JOURNAL OF EATING DISORDERS, 2011, 44 (07) : 585 - 595