Obesity and the brain: how convincing is the addiction model?

被引:297
作者
Ziauddeen, Hisham [1 ,2 ,3 ]
Farooqi, I. Sadaf [3 ]
Fletcher, Paul C. [1 ,2 ]
机构
[1] Univ Cambridge, Addenbrookes Hosp, Dept Psychiat, Cambridge CB2 0SZ, England
[2] Cambridgeshire Peterborough NHS Fdn Trust Fulbour, Cambridge CB21 5EF, England
[3] Univ Cambridge, Metab Res Labs, Inst Metab Sci, Addenbrookes Hosp, Cambridge CB2 0QQ, England
基金
英国惠康基金; 英国医学研究理事会;
关键词
DORSOLATERAL PREFRONTAL CORTEX; GENE TAQ1A POLYMORPHISM; DOPAMINE-RECEPTOR GENE; FOOD ADDICTION; DORSAL STRIATUM; ACCUMBENS DOPAMINE; EATING BEHAVIORS; LESS ACTIVATION; D2; RECEPTORS; NEURAL BASIS;
D O I
10.1038/nrn3212
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
An increasingly influential perspective conceptualizes both obesity and overeating as a food addiction accompanied by corresponding brain changes. Because there are far-reaching implications for clinical practice and social policy if it becomes widely accepted, a critical evaluation of this model is important. We examine the current evidence for the link between addiction and obesity, identifying several fundamental shortcomings in the model, as well as weaknesses and inconsistencies in the empirical support for it from human neuroscientific research.
引用
收藏
页码:279 / 286
页数:8
相关论文
共 101 条
[1]   Neurobiological evidence for hedonic allostasis associated with escalating cocaine use [J].
Ahmed S.H. ;
Kenny P.J. ;
Koob G.F. ;
Markou A. .
Nature Neuroscience, 2002, 5 (7) :625-626
[2]  
[Anonymous], 2000, DIAGN STAT MAN MENT
[3]   Sucrose sham feeding on a binge schedule releases accumbens dopamine repeatedly and eliminates the acetylcholine satiety response [J].
Avena, N. M. ;
Rada, P. ;
Moise, N. ;
Hoebel, B. G. .
NEUROSCIENCE, 2006, 139 (03) :813-820
[4]   Evidence for sugar addiction: Behavioral and neurochemical effects of intermittent, excessive sugar intake [J].
Avena, Nicole M. ;
Rada, Pedro ;
Hoebel, Bartley G. .
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2008, 32 (01) :20-39
[5]   Sugar and Fat Bingeing Have Notable Differences in Addictive-like Behavior [J].
Avena, Nicole M. ;
Rada, Pedro ;
Hoebel, Bartley G. .
JOURNAL OF NUTRITION, 2009, 139 (03) :623-628
[6]   Sugar-dependent rats show enhanced responding for sugar after abstinence: Evidence of a sugar deprivation effect [J].
Avena, NM ;
Long, KA ;
Hoebel, BG .
PHYSIOLOGY & BEHAVIOR, 2005, 84 (03) :359-362
[7]   Body mass correlates inversely with inhibitory control in response to food among adolescent girls: An fMRI study [J].
Batterink, Laura ;
Yokum, Sonja ;
Stice, Eric .
NEUROIMAGE, 2010, 52 (04) :1696-1703
[8]   The plausibility of sugar addiction and its role in obesity and eating disorders [J].
Benton, David .
CLINICAL NUTRITION, 2010, 29 (03) :288-303
[9]   Rats that binge eat fat-rich food do not show somatic signs or anxiety associated with opiate-like withdrawal: Implications for nutrient-specific food addiction behaviors [J].
Bocarsly, Miriam E. ;
Berner, Laura A. ;
Hoebel, Bartley G. ;
Avena, Nicole M. .
PHYSIOLOGY & BEHAVIOR, 2011, 104 (05) :865-872
[10]   Reward Abnormalities among Women with Full and Subthreshold Bulimia Nervosa: A Functional Magnetic Resonance Imaging Study [J].
Bohon, Cara ;
Stice, Eric .
INTERNATIONAL JOURNAL OF EATING DISORDERS, 2011, 44 (07) :585-595