Acid acclimation by Helicobacter pylori

被引：101
作者：
Sachs, G [1 ]
Weeks, DL
Wen, Y
Marcus, EA
Scott, DR
Melchers, K
机构：
[1] Univ Calif Los Angeles, David Geffen Sch Med, Lab Membrane Biol, Los Angeles, CA 90024 USA
[2] Vet Affairs Greater Los Angeles Hlth Care Syst, Los Angeles, CA USA
[3] Altana Res Inst, Boston, MA USA
来源：
PHYSIOLOGY | 2005年 / 20卷
关键词：
D O I：
10.1152/physiol.00032.2005
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Helicobacter pylori is a Gram-negative neutralophile associated with peptic ulcers and gastric cancer. It has a unique ability to colonize the human stomach by acid acclimation. It uses the pH-gated urea channel, Urel, to enhance urea access to intrabacterial urease and a membrane-anchored periplasmic carbonic anhydrase to regulate periplasmic pH to similar to 6.1 in acidic media, whereas other neutralophiles cannot regulate periplasmic pH and thus only transit the stomach.
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页码：429 / 438
页数：10
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