Acid acclimation by Helicobacter pylori

被引：101
|
作者：
Sachs, G [1 ]
Weeks, DL
Wen, Y
Marcus, EA
Scott, DR
Melchers, K
机构：
[1] Univ Calif Los Angeles, David Geffen Sch Med, Lab Membrane Biol, Los Angeles, CA 90024 USA
[2] Vet Affairs Greater Los Angeles Hlth Care Syst, Los Angeles, CA USA
[3] Altana Res Inst, Boston, MA USA
来源：
PHYSIOLOGY | 2005年 / 20卷
关键词：
D O I：
10.1152/physiol.00032.2005
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Helicobacter pylori is a Gram-negative neutralophile associated with peptic ulcers and gastric cancer. It has a unique ability to colonize the human stomach by acid acclimation. It uses the pH-gated urea channel, Urel, to enhance urea access to intrabacterial urease and a membrane-anchored periplasmic carbonic anhydrase to regulate periplasmic pH to similar to 6.1 in acidic media, whereas other neutralophiles cannot regulate periplasmic pH and thus only transit the stomach.
引用
收藏
页码：429 / 438
页数：10
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