Characterization of the bovine kappa-Casein gene promoter

被引：10

作者：

Adachi, T

Ahn, JY

Yamamoto, K

Aoki, N

Nakamura, R

Matsuda, T

机构：

[1] Department of Applied Biological Sciences, School of Agricultural Sciences, Nagoya University, Nagoya, 464-01, Chikusa-ku

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1996年 / 60卷 / 12期

关键词：

casein; milk protein; gene expression; promoter;

D O I：

10.1271/bbb.60.1937

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

kappa-Casein gene promoter was localized within a 570-bp fragment (-552/+18) of a 5'-flanking region by the gene transfection assay, Deletion mutation analysis in mammary epithelial cell line, HC11, suggested that there are regulatory element in a region from -439 through -125, Some nuclear proteins from lactating rate mammary gland bind to this region specifically, One of them expressed preferentially during pregnancy bound to a 132-bp fragment (-439/-308) and another expressed preferentially during lactation bound to a 183-bp fragment (-307/-125).

引用

页码：1937 / 1940

页数：4

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