Transition-metal-free visible-light photoredox catalysis at room-temperature for decarboxylative fluorination of aliphatic carboxylic acids by organic dyes

被引：96
|
作者：
Wu, Xinxin [1 ]
Meng, Chunna [1 ]
Yuan, Xiaoqian [1 ]
Jia, Xiaotong [2 ]
Qian, Xuhong [2 ]
Ye, Jinxing [1 ,3 ]
机构：
[1] E China Univ Sci & Technol, Sch Pharm, Minist Educ, Engn Res Ctr Pharmaceut Proc Chem, Shanghai 200237, Peoples R China
[2] E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China
[3] E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 59期
基金：
中国国家自然科学基金;
关键词：
C-H BONDS; FLUORIDE-ION; TRIFLUOROMETHYLATION; ACTIVATION; PHOTOOXIDATION; HETEROARENES; CHEMISTRY; ALKENES;
D O I：
10.1039/c5cc04527d
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We report herein an efficient, general and green method for decarboxylative fluorination of aliphatic carboxylic acids. By using a transition-metal-free, organocatalytic photoredox system, the reaction of various aliphatic carboxylic acids with the Selectfluor reagent afforded the corresponding alkyl fluorides in satisfactory yields under visible light irradiation at room temperature.
引用
收藏
页码：11864 / 11867
页数：4
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