An efficient regioselective synthesis of highly functionalized 3-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidines via an isocyanide-based three-component reaction

被引：24
|
作者：
Esmaeili, Abbas Ali [1 ,2 ]
Zangouei, Mandieh [1 ]
Fakhari, Ali Reza [3 ]
Habibi, Azizollah [4 ]
机构：
[1] Univ Birjand, Dept Chem, Birjand, Iran
[2] Ferdowsi Univ Mashhad, Dept Chem, Mashhad, Iran
[3] Shahid Beheshti Univ, Fac Sci, Dept Chem, GC, Tehran, Iran
[4] Univ Tarbiatmoallem, Fac Chem, Tehran 1571914911, Iran
来源：
TETRAHEDRON LETTERS | 2012年 / 53卷 / 11期
关键词：
2-Imino-1,3-thiazolidin-4-one; Dialkyl acetylenedicarboxylates; Alkyl isocyanides; Thiazolo[3,2-a]pyrimidine; ASSISTED COMBINATORIAL SYNTHESIS; ONE-POT SYNTHESIS; MULTICOMPONENT REACTIONS; CONVENIENT SYNTHESIS; DERIVATIVES; THIAZOLOPYRIMIDINES; PYRIMIDINE; LIBRARIES; ROUTE; ACID;
D O I：
10.1016/j.tetlet.2012.01.005
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We present a novel, convenient, and efficient method for synthesizing polysubstituted 3-oxo-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidines via a three-component reaction. The zwitterions generated from the reaction of isocyanides and dialkyl acetylenedicarboxylates react with 2-imino-1,3-thiazolidin-4-one to produce the title compounds in good yields. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1351 / 1353
页数：3
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