An efficient regioselective synthesis of highly functionalized 3-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidines via an isocyanide-based three-component reaction

被引：24

作者：

Esmaeili, Abbas Ali ^{[1
,2
]}

Zangouei, Mandieh ^{[1
]}

Fakhari, Ali Reza ^{[3
]}

Habibi, Azizollah ^{[4
]}

机构：

[1] Univ Birjand, Dept Chem, Birjand, Iran

[2] Ferdowsi Univ Mashhad, Dept Chem, Mashhad, Iran

[3] Shahid Beheshti Univ, Fac Sci, Dept Chem, GC, Tehran, Iran

[4] Univ Tarbiatmoallem, Fac Chem, Tehran 1571914911, Iran

来源：

TETRAHEDRON LETTERS | 2012年 / 53卷 / 11期

关键词：

2-Imino-1,3-thiazolidin-4-one; Dialkyl acetylenedicarboxylates; Alkyl isocyanides; Thiazolo[3,2-a]pyrimidine; ASSISTED COMBINATORIAL SYNTHESIS; ONE-POT SYNTHESIS; MULTICOMPONENT REACTIONS; CONVENIENT SYNTHESIS; DERIVATIVES; THIAZOLOPYRIMIDINES; PYRIMIDINE; LIBRARIES; ROUTE; ACID;

D O I：

10.1016/j.tetlet.2012.01.005

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We present a novel, convenient, and efficient method for synthesizing polysubstituted 3-oxo-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidines via a three-component reaction. The zwitterions generated from the reaction of isocyanides and dialkyl acetylenedicarboxylates react with 2-imino-1,3-thiazolidin-4-one to produce the title compounds in good yields. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：1351 / 1353

页数：3

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