Protective effect of ginseng sapogenins against 2,2′-azobis (1-aminopropane) dihydrochloride (AAPH)-induced LLC-PK1 cell damage

被引：13

作者：

Kang, Ki Sung ^{[6
]}

Kim, Hyun Young ^{[5
]}

Yoo, Hye Hyun ^{[4
]}

Piao, Xiang Lan ^{[3
]}

Ham, Jungyeob ^{[6
]}

Yang, Hyun Ok ^{[6
]}

Park, Jeong Hill ^{[1
,2
]}

机构：

[1] Seoul Natl Univ, Pharmaceut Sci Res Inst, Seoul 151742, South Korea

[2] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea

[3] Minzu Univ China, Inst Chinese Minor Tradit Med, Beijing 100081, Peoples R China

[4] Hanyang Univ, Coll Pharm, Ansan 426791, Gyeonggi Do, South Korea

[5] Gyeongnam Natl Univ Sci & Technol, Dept Food Sci, Jinju 660758, South Korea

[6] Korea Inst Sci & Technol, Nat Med Ctr, Kangnung 210340, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2012年 / 22卷 / 01期

关键词：

Panax ginseng; Renoprotective activity; Ginsenoside; Sapogenin; RADICAL-SCAVENGING ACTIVITY; HEAT-PROCESSED GINSENG; DIABETIC-NEPHROPATHY; RENAL DAMAGE; GINSENOSIDES; OXYGEN; ANTIOXIDANT; REDUCTION; RATS; RB-1;

D O I：

10.1016/j.bmcl.2011.10.063

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The effect of ginseng sapogenins, aglycone parts of ginsenosides, against oxidative damage by radical generator, 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH), in renal epithelial LLC-PK1 cells was investigated to identify the structural characteristics of sapogenins to have renoprotective effects. Of the tested sapogenins, Delta(20(21))-protopanaxatriol showed the strongest protective effect against the AAPH-induced LLC-PK1 cell damage. Based on the structure and stronger activity of Delta(20(21))-protopanaxatriol than the other sapogenins, the hydroxyl group in C-6 and double bond in C-20(21) position were important for renoprotective effect of sapogenin against oxidative stress. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：634 / 637

页数：4

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