Env length and N-linked glycosylation following transmission of human immunodeficiency virus Type 1 subtype B viruses

被引：67

作者：

Liu, Yi ^{[1
]}

Curlin, Marcel E. ^{[1
]}

Diem, Kurt ^{[2
]}

Zhao, Hong ^{[1
]}

Ghosh, Ananta K. ^{[1
]}

Zhu, Haiying ^{[2
]}

Woodward, Amanda S. ^{[2
]}

Maenza, Janine ^{[3
]}

Stevens, Claire E. ^{[3
]}

Stekler, Joanne ^{[3
]}

Collier, Ann C. ^{[3
]}

Genowati, Indira ^{[1
]}

Deng, Wenjie ^{[1
]}

Zioni, Rafael ^{[2
]}

Corey, Lawrence ^{[2
,3
,4
]}

Zhu, Tuofu ^{[1
,2
]}

Mullins, James I. ^{[1
,2
,3
]}

机构：

[1] Univ Washington, Sch Med, Dept Microbiol, Seattle, WA 98195 USA

[2] Univ Washington, Sch Med, Dept Lab Med, Seattle, WA 98195 USA

[3] Univ Washington, Sch Med, Dept Med, Seattle, WA 98195 USA

[4] Fred Hutchinson Canc Res Ctr, Dept Program Infect Dis, Seattle, WA 98109 USA

来源：

VIROLOGY | 2008年 / 374卷 / 02期

关键词：

HIV-1; Env sequence length; N-linked glycosylation sites; transmission; primary infection;

D O I：

10.1016/j.virol.2008.01.029

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Whether there is selection for specific viral Env variants upon HIV-1 transmission is controversial. We examined the V1V2 and V1V4 regions of Env in 10 new and 8 previously described transmission pairs infected with HIV-1 subtype B, including a total of 9 pairs in which the infecting partner had developed substantial viral diversity prior to transmission. We found that during transmission of HIV-1 subtype B, as well as for other subtypes reported in the past, viral populations in recipients undergo substantial genetic bottlenecks, as well as weak evidence for a propensity to replicate viruses with shorter variable loops and fewer potential N-linked glycosylation sites. (c) 2008 Elsevier Inc. All rights reserved.

引用

页码：229 / 233

页数：5

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