Secondary Metabolites from an Algicolous Aspergillus versicolor Strain

被引：65

作者：

Miao, Feng-Ping ^{[1
]}

Li, Xiao-Dong ^{[1
]}

Liu, Xiang-Hong ^{[1
]}

Cichewicz, Robert H. ^{[2
]}

Ji, Nai-Yun ^{[1
]}

机构：

[1] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China

[2] Univ Oklahoma, Dept Chem & Biochem, Nat Prod Discovery Grp, Norman, OK 73019 USA

来源：

MARINE DRUGS | 2012年 / 10卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Sargassum thunbergii; Aspergillus versicolor; asperversin A; 9 xi-O-2(2,3-dimethylbut-3-enyl)brevianamide Q; ASSIGNMENTS;

D O I：

10.3390/md10010131

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new compounds, asperversin A (1) and 9 xi-O-2(2,3-dimethylbut-3-enyl)brevianamide Q (2), and nine known compounds, brevianamide K (3), brevianamide M (4), aversin (5), 6,8-di-O-methylnidurufin (6), 6,8-di-O-methylaverufin (7), 6-O-methylaverufin (8), 5 alpha,8 alpha-epidioxyergosta-6,22-dien-3 beta-ol (9), ergosta-7,22-diene-3 beta,5 alpha,6 beta-triol (10), and 6 beta-methoxyergosta-7,22-diene-3 beta,5 alpha-diol (11), were obtained from the culture of Aspergillus versicolor, an endophytic fungus isolated from the marine brown alga Sargassum thunbergii. The structures of these compounds were established by spectroscopic techniques. Compounds 4, 7 and 8 exhibited antibacterial activities against Escherichia coli and Staphyloccocus aureus, and 7 also showed lethality against brine shrimp (Artemia salina) with an LC(50) value of 0.5 mu g/mL.

引用

页码：131 / 139

页数：9

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