A role for inflammatory cytokines in the productive activation of antigen-specific CD4+ T-cells

被引：0
|
作者：
Pape, KA [1 ]
Jenkins, MK [1 ]
机构：
[1] Univ Minnesota, Sch Med, Dept Microbiol, Minneapolis, MN 55455 USA
来源：
THERAPEUTIC STRATEGIES FOR MODULATING THE INFLAMMATORY DISEASES | 1998年 / 49卷
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D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The mechanisms of action of immunological adjuvants were studied using a system in which the behavior of adoptively transferred CD4(+) T-cell receptor transgenic T-cells could be directly monitored following antigen administration. These studies revealed that adjuvant-induced inflammatory cytokines promote immunity by enhancing the clonal expansion, persistence and differentiation of antigen-activated CD4(+) T-cells.
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页码：23 / 31
页数：9
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