A role for inflammatory cytokines in the productive activation of antigen-specific CD4+ T-cells

被引：0

作者：

Pape, KA ^{[1
]}

Jenkins, MK ^{[1
]}

机构：

[1] Univ Minnesota, Sch Med, Dept Microbiol, Minneapolis, MN 55455 USA

来源：

THERAPEUTIC STRATEGIES FOR MODULATING THE INFLAMMATORY DISEASES | 1998年 / 49卷

关键词：

D O I：

暂无

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The mechanisms of action of immunological adjuvants were studied using a system in which the behavior of adoptively transferred CD4(+) T-cell receptor transgenic T-cells could be directly monitored following antigen administration. These studies revealed that adjuvant-induced inflammatory cytokines promote immunity by enhancing the clonal expansion, persistence and differentiation of antigen-activated CD4(+) T-cells.

引用

页码：23 / 31

页数：9

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