Effect of early postnatal air-conduction auditory deprivation on the development and function of the rat spiral ganglion

被引：5
作者：
Wang, F. [1 ,2 ]
Gao, X. [2 ,3 ]
Chen, J. [2 ]
Liu, S-L [2 ]
Wang, F-Y [2 ]
Hei, R-Y [2 ]
Chen, Y. [2 ]
Qiu, J-H [2 ]
机构：
[1] Gen Hosp AF, Dept Otolaryngol, Beijing, Peoples R China
[2] Fourth Mil Med Univ, Dept Otorhinolaryngol Head & Neck Surg, Xijing Hosp, Xian 710032, Shaanxi, Peoples R China
[3] Gen Hosp Second Artillery, Dept Otorhinolaryngol Head & Neck Surg, Beijing, Peoples R China
来源：
JOURNAL OF LARYNGOLOGY AND OTOLOGY | 2011年 / 125卷 / 09期
基金：
中国国家自然科学基金;
关键词：
Cochlea; Rats; Spiral Ganglion; Sensory Deprivation; Neuron-Specific Enolase; Hearing; EVOKED POTENTIALS; HEARING-LOSS; CORTEX; STIMULATION; EXPOSURE; NEURONS; NUCLEI;
D O I：
10.1017/S0022215111001356
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Objective: To evaluate the effect of early postnatal air-conduction auditory deprivation on the development and function of the rat spiral ganglion. Study design: Randomised animal study. Methods: Sixty neonatal Sprague-Dawley rats were randomly divided into two groups: controls (n = 30) given regular chow and water ad libitum; and study animals (n = 30) fed within a soundproof chamber. Auditory brainstem response testing was conducted in both groups on postnatal day 42. Results: Auditory deprivation between postnatal days 12 and 42 resulted in an increased hearing threshold and reduced auditory brainstem response amplitudes, together with degeneration of type I spiral ganglion neurons and the presence of apoptotic cells. Conclusion: Non-invasive auditory deprivation during a critical developmental period resulted in numerous changes in rat cochlear function and morphology.
引用
收藏
页码：917 / 923
页数：7
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