Dispensable role of PTEN in mouse spermatogenesis

被引：8

作者：

Huang, Yue ^{[1
]}

Mao, Xia ^{[1
]}

Boyce, Terry ^{[1
]}

Zhu, Guo-Zhang ^{[1
]}

机构：

[1] Marshall Univ, Dept Biol, Huntington, WV 25755 USA

来源：

CELL BIOLOGY INTERNATIONAL | 2011年 / 35卷 / 09期

关键词：

Akt; conditional knockout; male germ cell; PTEN; spermatogenesis; MALE GERM-CELLS; PHOSPHOINOSITIDE 3-KINASE PATHWAY; TUMOR-SUPPRESSOR GENE; SPERM; PHOSPHATASE; MICE; DIFFERENTIATION; BIOLOGY; KINASE;

D O I：

10.1042/CBI20110161

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

PTEN (phosphatase and tensin homologue deleted on chromosome ten) plays critical roles in multiple cellular processes, including cell proliferation, survival, migration and transformation. A role of PTEN in mammalian spermatogenesis, however, has not been explored. To address this question, we generated a mouse model with PTEN conditional knockout in postnatal male germ cells. We found that spermatogenesis was normal in PTEN-deleted male germ cells. PTEN conditional mutant males produced sperm and sired offspring as competently as wild-type littermates. Moreover, our biochemical analysis also indicated that the Akt (acutely transforming retrovirus AKT8 in rodent T cell lymphoma) signalling pathway was not affected in mutant testis. Taken together, these findings demonstrate that PTEN is dispensable in mouse spermatogenesis.

引用

页码：905 / 908

页数：4

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