"Messieurs, c'est les microbes qui auront le dernier mot": Gentlemen, it is the microbes who have the last word (Louis Pasteur)-Fusobacterium nucleatum protect tumors from killing by immune cells

被引：7

作者：

Gur, Chamutal ^{[1
,2
]}

Mandelboim, Ofer ^{[1
]}

Bachrach, Gilad ^{[3
]}

机构：

[1] Hebrew Univ Jerusalem, Hadassah Med Sch, Lautenberg Ctr Gen & Tumor Immunol, IMRIC, IL-91010 Jerusalem, Israel

[2] Hadassah Hebrew Univ, Rheumatol Res Ctr, Jerusalem, Israel

[3] Hebrew Univ Jerusalem, Hadassah Sch Dent Med, Inst Dent Sci, IL-91010 Jerusalem, Israel

来源：

ONCOIMMUNOLOGY | 2015年 / 4卷 / 09期

关键词：

tumor immunity; NK cells; fusobacteria; colon adenocarcinoma; FUSOBACTERIUM-NUCLEATUM;

D O I：

10.1080/2162402X.2015.1038690

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Fusobacterium nucleatum is present in colon cancers where it was shown to generate a proinflammatory microenvironment that supports colorectal neoplasia progression. Remarkably, alongside with proinflammatory stimulation, fusobacteria also inhibit cytotoxicity of immune cells. Thus, it appears as if tumors exploit fusobacteria to generate a favorable proinflammatory and anti-cytotoxic microenvironment.

引用

页码：1 / 3

页数：3

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