"Messieurs, c'est les microbes qui auront le dernier mot": Gentlemen, it is the microbes who have the last word (Louis Pasteur)-Fusobacterium nucleatum protect tumors from killing by immune cells

被引：7
作者：
Gur, Chamutal [1 ,2 ]
Mandelboim, Ofer [1 ]
Bachrach, Gilad [3 ]
机构：
[1] Hebrew Univ Jerusalem, Hadassah Med Sch, Lautenberg Ctr Gen & Tumor Immunol, IMRIC, IL-91010 Jerusalem, Israel
[2] Hadassah Hebrew Univ, Rheumatol Res Ctr, Jerusalem, Israel
[3] Hebrew Univ Jerusalem, Hadassah Sch Dent Med, Inst Dent Sci, IL-91010 Jerusalem, Israel
来源：
ONCOIMMUNOLOGY | 2015年 / 4卷 / 09期
关键词：
tumor immunity; NK cells; fusobacteria; colon adenocarcinoma; FUSOBACTERIUM-NUCLEATUM;
D O I：
10.1080/2162402X.2015.1038690
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Fusobacterium nucleatum is present in colon cancers where it was shown to generate a proinflammatory microenvironment that supports colorectal neoplasia progression. Remarkably, alongside with proinflammatory stimulation, fusobacteria also inhibit cytotoxicity of immune cells. Thus, it appears as if tumors exploit fusobacteria to generate a favorable proinflammatory and anti-cytotoxic microenvironment.
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页码：1 / 3
页数：3
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  • [1] Direct Recognition of Fusobacterium nucleatum by the NK Cell Natural Cytotoxicity Receptor NKp46 Aggravates Periodontal Disease
    Chaushu, Stella
    Wilensky, Asaf
    Gur, Chamutal
    Shapira, Lior
    Elboim, Moran
    Halftek, Gili
    Polak, David
    Achdout, Hagit
    Bachrach, Gilad
    Mandelboim, Ofer
    [J]. PLOS PATHOGENS, 2012, 8 (03)
  • [2] VIRUS PARTICLES IN CULTURED LYMPHOBLASTS FROM BURKITTS LYMPHOMA
    EPSTEIN, MA
    ACHONG, BG
    BARR, YM
    [J]. LANCET, 1964, 1 (733) : 702 - +
  • [3] Binding of the Fap2 Protein of Fusobacterium nucleatum to Human Inhibitory Receptor TIGIT Protects Tumors from Immune Cell Attack
    Gur, Chamutal
    Ibrahim, Yara
    Isaacson, Batya
    Yamin, Rachel
    Abed, Jawad
    Gamliel, Moriya
    Enk, Jonatan
    Bar-On, Yotam
    Stanietsky-Kaynan, Noah
    Coppenhagen-Glazer, Shunit
    Shussman, Noam
    Almogy, Gideon
    Cuapio, Angelica
    Hofer, Erhard
    Mevorach, Dror
    Tabib, Adi
    Ortenberg, Rona
    Markel, Gal
    Miklic, Karmela
    Jonjic, Stipan
    Brennan, Caitlin A.
    Garrett, Wendy S.
    Bachrach, Gilad
    Mandelboim, Ofer
    [J]. IMMUNITY, 2015, 42 (02) : 344 - 355
  • [4] Natural Killer Cell-Mediated Host Defense against Uropathogenic E. coli Is Counteracted by Bacterial HemolysinA-Dependent Killing of NK Cells
    Gur, Chamutal
    Coppenhagen-Glazer, Shunit
    Rosenberg, Shilo
    Yamin, Rachel
    Enk, Jonatan
    Glasner, Ariella
    Bar-On, Yotam
    Fleissig, Omer
    Naor, Ronit
    Abed, Jawad
    Mevorach, Dror
    Granot, Zvi
    Bachrach, Gilad
    Mandelboim, Ofer
    [J]. CELL HOST & MICROBE, 2013, 14 (06) : 664 - 674
  • [5] Fusobacterium nucleatum apoptosis-inducing outer membrane protein
    Kaplan, CW
    Lux, R
    Huynh, T
    Jewett, A
    Shi, W
    Haake, SK
    [J]. JOURNAL OF DENTAL RESEARCH, 2005, 84 (08) : 700 - 704
  • [6] Fusobacterium nucleatum Potentiates Intestinal Tumorigenesis and Modulates the Tumor-Immune Microenvironment
    Kostic, Aleksandar D.
    Chun, Eunyoung
    Robertson, Lauren
    Glickman, Jonathan N.
    Gallini, Carey Ann
    Michaud, Monia
    Clancy, Thomas E.
    Chung, Daniel C.
    Lochhead, Paul
    Hold, Georgina L.
    El-Omar, Emad M.
    Brenner, Dean
    Fuchs, Charles S.
    Meyerson, Matthew
    Garrett, Wendy S.
    [J]. CELL HOST & MICROBE, 2013, 14 (02) : 207 - 215
  • [7] A sarcoma of the fowl transmissible by an agent from the tumor cells.
    Rous, P
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1911, 13 (04) : 397 - 411
  • [8] Fusobacterium nucleatum Promotes Colorectal Carcinogenesis by Modulating E-Cadherin/β-Catenin Signaling via its FadA Adhesin
    Rubinstein, Mara Roxana
    Wang, Xiaowei
    Liu, Wendy
    Hao, Yujun
    Cai, Guifang
    Han, Yiping W.
    [J]. CELL HOST & MICROBE, 2013, 14 (02) : 195 - 206
  • [9] A bacterial driver-passenger model for colorectal cancer: beyond the usual suspects
    Tjalsma, Harold
    Boleij, Annemarie
    Marchesi, Julian R.
    Dutilh, Bas E.
    [J]. NATURE REVIEWS MICROBIOLOGY, 2012, 10 (08) : 575 - 582
  • [10] The Search for Infectious Causes of Human Cancers: Where and Why (Nobel Lecture)
    zur Hausen, Harald
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2009, 48 (32) : 5798 - 5808
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