Serum Anticytokine Autoantibody Levels Are Not Increased in Hidradenitis Suppurativa: A Case-Control Pilot Study

被引:4
|
作者
Riis, Peter Theut [1 ]
von Stemann, Jakob Hjorth [2 ,3 ]
Andersen, Rune Kjaersgaard [1 ]
Hansen, Morten Bagge [2 ,3 ]
Jemec, Gregor B. E. [1 ]
机构
[1] Zealand Univ Hosp, Dept Dermatol, Sygehusvej 5, DK-4000 Roskilde, Denmark
[2] Copenhagen Univ Hosp, Rigshosp, Dept Clin Immunol, Copenhagen, Denmark
[3] Copenhagen Univ Hosp, Rigshosp, Blood Bank, Copenhagen, Denmark
关键词
Hidradenitis suppurativa; Acne inversa; Cytokines; Anticytokine autoantibodies; SKIN;
D O I
10.1159/000475925
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background: Hidradenitis suppurativa is a skin disease of recurrent episodes of inflammatory nodules, abscesses, and scarring of the intertriginous regions, e.g. the axillae and groin. A dysregulated immune response to one or more unknown antigens in hidradenitis suppurativa has been suggested. One hypothetical element of this dysregulation may be the functionality of the cytokines. This study examines the serum level of anticytokine autoantibodies for interleukin (IL)-1 alpha, IL-6, IL-10, IL-17A, IL-17E, IL-17F, and interferon-alpha. Method: Recombinant, carrier-free cytokines were coupled to microspheres. The coupled beads were incubated for 1 h in the dark with assay buffer-diluted sera, and subsequently for 30 min with polyclonal goat F(ab')(2) anti-human IgG phycoerythrin- conjugated antibody. Data are presented as the median fluorescence intensity of samples. Results: No difference in levels of anticytokine autoantibodies was demonstrated for any of the autoantibodies studied. Discussion: The data suggest that endogenously produced autoantibodies only play a minor role, if any, in hidradenitis suppurativa. (C) 2017 S. Karger AG, Basel
引用
收藏
页码:126 / 128
页数:3
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