Airway Microbiota as a Modulator of Lung Cancer

被引：42

作者：

Goto, Taichiro ^{[1
]}

机构：

[1] Yamanashi Cent Hosp, Lung Canc & Resp Dis Ctr, Kofu, Yamanashi 4008506, Japan

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 09期

关键词：

microbiome; lung cancer; oncogenesis; inflammation; FUSOBACTERIUM-NUCLEATUM; BRONCHIAL MICROBIOME; CHLAMYDIA-PNEUMONIAE; ASTHMA; RISK; INFECTION; DISEASE; IMMUNOTHERAPY; PATHOGENESIS; PROGRESSION;

D O I：

10.3390/ijms21093044

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent research on cancer-associated microbial communities has elucidated the interplay between bacteria, immune cells, and tumor cells; the bacterial pathways involved in the induction of carcinogenesis; and their clinical significance. Although accumulating evidence shows that a dysbiotic condition is associated with lung carcinogenesis, the underlying mechanisms remain unclear. Microorganisms possibly trigger tumor initiation and progression, presumably via the production of bacterial toxins and other pro-inflammatory factors. The purpose of this review is to discuss the basic role of the airway microbiome in carcinogenesis and the underlying molecular mechanisms, with the aim of developing anticancer strategies involving the airway microbiota. In addition, the mechanisms via which the microbiome acts as a modulator of immunotherapies in lung cancer are summarized.

引用

页数：19

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