Hydrogel adhesive formed via multiple chemical interactions: from persistent wet adhesion to rapid hemostasis

被引:21
作者
Liang, Min [1 ]
Wei, Dandan [1 ]
Yao, Zhangyu [2 ]
Ren, Pengfei [1 ]
Dai, Jidong [1 ]
Xu, Li [1 ]
Zhang, Tianzhu [1 ]
Zhang, Qianli [3 ]
机构
[1] Southeast Univ, Natl Demonstrat Ctr Expt Biomed Engn Educ, Sch Biol Sci & Med Engn, State Key Lab Bioelect, Nanjing 210096, Peoples R China
[2] Nanjing Med Univ, Affiliated Canc Hosp, Dept Head & Neck Surg, Nanjing 210009, Peoples R China
[3] Suzhou Univ Sci & Technol, Sch Chem & Life Sci, Suzhou 215009, Peoples R China
基金
中国国家自然科学基金;
关键词
ROBUST; TOUGH; ANTIBACTERIAL; PARTICLES; CHITOSAN;
D O I
10.1039/d1bm01848e
中图分类号
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号
0805 ; 080501 ; 080502 ;
摘要
To date, the robust and durable adhesion capability of hydrogel adhesives in wet environments remains a huge challenge. Herein, a physicochemically double-network crosslinked hydrogel matrix was prepared by mixing acrylic acid (AAc), chitosan (CS) and tannic acid (TA) as the main components and the subsequent in situ polymerization of AAc. The abundant reactive sites on the surface of the hydrogel matrix facilitate rapid, strong and repeatable adhesion to different surfaces of engineering solids and biological tissues in an aquatic environment. The formation of amide covalent bonds resulting from the addition of the bridging agent further expands the long-term application of the hydrogel in tissue repair, and the constructed hydrogel-tissue adhesive interface still has robust adhesion energy after soaking in a physiological environment for up to one month. Moreover, the hydrogel showed fantastic hemostatic performance due to its characteristics of platelet adhesion and high burst pressure. Overall, the persistent adhesion and excellent cytocompatibility of the hydrogel adhesive make it potentially applicable in medical adhesives.
引用
收藏
页码:1486 / 1497
页数:12
相关论文
共 53 条
[31]   Nonthrombogenic Hydrogel Coatings with Carbene-Cross-Linking Bioadhesives [J].
Nanda, Himansu Sekhar ;
Shah, Ankur Harish ;
Wicaksono, Gautama ;
Pokholenko, Oleksandr ;
Gao, Feng ;
Djordjevic, Ivan ;
Steele, Terry W. J. .
BIOMACROMOLECULES, 2018, 19 (05) :1425-1434
[32]   Mussel-inspired elastic interpenetrated network hydrogel as an alternative for anti-thrombotic stent coating membrane [J].
Obiweluozor, Francis O. ;
Maharjan, Bikendra ;
Emechebe, A. Gladys ;
Park, Chan Hee ;
Kim, Cheol Sang .
CHEMICAL ENGINEERING JOURNAL, 2018, 347 :932-943
[33]   Tunicate-mimetic nanofibrous hydrogel adhesive with improved wet adhesion [J].
Oh, Dongyeop X. ;
Kim, Sangsik ;
Lee, Dohoon ;
Hwang, Dong Soo .
ACTA BIOMATERIALIA, 2015, 20 :104-112
[34]   Hydrogel networks as underwater contact adhesives for different surfaces [J].
Pan, Feng ;
Ye, Shaoxiong ;
Wang, Ruixing ;
She, Wei ;
Liu, Jiaping ;
Sun, ZhengMing ;
Zhang, Wei .
MATERIALS HORIZONS, 2020, 7 (08) :2063-2070
[35]   A review on tough and sticky hydrogels [J].
Peak, Charles W. ;
Wilker, Jonathan J. ;
Schmidt, Gudrun .
COLLOID AND POLYMER SCIENCE, 2013, 291 (09) :2031-2047
[36]   Bioresponsive supramolecular hydrogels for hemostasis, infection control and accelerated dermal wound healing [J].
Preman, Namitha K. ;
Priya, Sindhu E. S. ;
Prabhu, Ashwini ;
Shaikh, Sadiya Bi ;
Vipin, C. ;
Barki, Rashmi R. ;
Bhandary, Yashodhar P. ;
Rekha, P. D. ;
Johnson, Renjith P. .
JOURNAL OF MATERIALS CHEMISTRY B, 2020, 8 (37) :8585-8598
[37]   A mussel-inspired supramolecular hydrogel with robust tissue anchor for rapid hemostasis of arterial and visceral bleedings [J].
Qiao, Ziwen ;
Lv, Xueli ;
He, Shaohua ;
Bai, Shumeng ;
Liu, Xiaochen ;
Hou, Linxi ;
He, Jingjing ;
Tong, Dongmei ;
Ruan, Renjie ;
Zhang, Jin ;
Ding, Jianxun ;
Yang, Huanghao .
BIOACTIVE MATERIALS, 2021, 6 (09) :2829-2840
[38]   INHIBITION OF TUMOR PROMOTION AND CELL-PROLIFERATION BY PLANT POLYPHENOLS [J].
RAMANATHAN, R ;
DAS, NP ;
TAN, CH .
PHYTOTHERAPY RESEARCH, 1994, 8 (05) :293-296
[39]   One-Pot Covalent Grafting of Gelatin on Poly(Vinyl Alcohol) Hydrogel to Enhance Endothelialization and Hemocompatibility for Synthetic Vascular Graft Applications [J].
Rizwan, Muhammad ;
Yao, Yuan ;
Gorbet, Maud B. ;
Tse, John ;
Anderson, Deirdre E. J. ;
Hinds, Monica T. ;
Yim, Evelyn K. F. .
ACS APPLIED BIO MATERIALS, 2020, 3 (01) :693-703
[40]   Zwitterionic Nanogels and Microgels: An Overview on Their Synthesis and Applications [J].
Saha, Pabitra ;
Ganguly, Ritabrata ;
Li, Xin ;
Das, Rohan ;
Singha, Nikhil K. ;
Pich, Andrij .
MACROMOLECULAR RAPID COMMUNICATIONS, 2021, 42 (13)