Developmental expression of glycine receptor subunits in rat cerebellum

被引：9

作者：

Garcia-Alcocer, Guadalupe ^{[1
]}

Mejia, Carmen ^{[2
]}

Berumen, Laura C. ^{[1
]}

Miledi, Ricardo ^{[2
]}

Martinez-Torres, Ataulfo ^{[2
]}

机构：

[1] Univ Autonoma Queretaro, Ctr Univ, Fac Quim, Queretaro 76010, Mexico

[2] Univ Nacl Autonoma Mexico, Dept Neurobiol Celular & Mol, Inst Neurobiol, Juriquilla Queretaro 76230, Mexico

来源：

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE | 2008年 / 26卷 / 3-4期

关键词：

ion channel; neurotransmitter; Purkinje neuron; development;

D O I：

10.1016/j.ijdevneu.2008.01.005

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The distribution of the glycine receptor subunits alpha 1-3 and beta in the developing rat cerebellum was studied from postnatal day 1 to adulthood by means of quantitative RT-PCR and immunohistochemistry. qRT-PCR of postnatal cerebella indicated the presence of mRNA for each subunit, with a relative expression of alpha 2 > alpha 3 > alpha 1 > beta. The immunohistochemistry indicated a strong alpha 2 signal in the Purkinje cells, internal and external granular layers. The alpha 1-3 subunits had weak signals in the Purkinje cells and molecular layer. The alpha 1 subunit was expressed at a low level and was also found in the white matter. The function of these receptors in neuronal and glial plasma membranes in early postnatal development remains to be determined. (C) 2008 Published by Elsevier Ltd on behalf of ISDN.

引用

页码：319 / 322

页数：4

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