Trifluoromethyl alcohol and ketone inhibitors of metallo-beta-lactamases

被引：90

作者：

Walter, MW

Felici, A

Galleni, M

Soto, RP

Adlington, RM

Baldwin, JE

Frere, JM

Gololobov, M

Schofield, CJ

机构：

[1] UNIV LIEGE,ENZYMOL LAB,INST CHIM B6,B-4000 SART,LIEGE,BELGIUM

[2] DYSON PERRINS LAB,OXFORD OX1 3QY,ENGLAND

[3] UNIV OXFORD,OXFORD CTR MOL SCI,OXFORD OX1 3QY,ENGLAND

[4] UNIV AQUILA,CATTEDRA CHIM BIOL,LOCAL COLLEMAGGIO,I-67100 LAQUILA,ITALY

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 20期

关键词：

D O I：

10.1016/0960-894X(96)00453-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

a-Amido trifluoromethyl alcohols and ketones were synthesised via two independent routes using Ruppert's Reagent (TMS-CF3) and shown to be the first reported synthetic inhibitors of metallo-beta-lactamases. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：2455 / 2458

页数：4

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