Immune checkpoint blockade in human cancer therapy: lung cancer and hematologic malignancies

被引：50

作者：

Janakiram, Murali ^{[1
,2
,3
]}

Pareek, Vipul ^{[1
,2
]}

Cheng, Haiying ^{[1
,2
]}

Narasimhulu, Deepa M. ^{[2
]}

Zang, Xingxing ^{[1
,2
,3
,4
]}

机构：

[1] Montefiore Med Ctr, Albert Einstein Coll Med, Dept Med, Bronx, NY 10461 USA

[2] Montefiore Med Ctr, Albert Einstein Coll Med, Oncol, Bronx, NY 10461 USA

[3] Montefiore Med Ctr, Albert Einstein Coll Med, Microbiol & Immunol, Bronx, NY 10461 USA

[4] Montefiore Med Ctr, Albert Einstein Coll Med, Urol, Bronx, NY 10461 USA

来源：

IMMUNOTHERAPY | 2016年 / 8卷 / 07期

关键词：

CTLA-4; Hodgkin lymphoma; immune checkpoint inhibitor; immunotherapy; leukemia; multiple myeloma; non-lymphoma; non-small-cell lung cancer; PD-1; PD-L1; squamous cell lung cancer; PD-1; BLOCKADE; PHASE-II; CELL; COMBINATION; NIVOLUMAB; ANTIBODY; SAFETY; INFILTRATION; PIDILIZUMAB; IPILIMUMAB;

D O I：

10.2217/imt-2016-0001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Tumor immune evasion is one of the hallmarks of cancer, and expression of the B7 family of immune checkpoints (PD-L1, PD-L2, B7-H3, B7x and HHLA2) is one mechanism of immune evasion by tumors to suppress T-cell function. Antibodies blocking these interactions of B7-1/B7-2/CTLA-4 and PD-L1/PD-L2/ PD-1 have had remarkable clinical success in several cancers and are less toxic than traditional chemotherapy. Even though only a small proportion of patients respond to checkpoint blockade, the duration of such responders due to immunological memory is remarkable and is longer than would be expected with any other agent in refractory disease. In this article, we review the therapeutic trials of blocking these pathways in human lung cancer and hematological malignancies.

引用

页码：809 / 819

页数：11

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