Expression and release of LAG-3-encoded protein by human CD4(+) T cells are associated with IFN-gamma production

被引：96

作者：

Annunziato, F ^{[1
]}

Manetti, R ^{[1
]}

Tomasevic, L ^{[1
]}

Giudizi, MG ^{[1
]}

Biagiotti, R ^{[1
]}

Gianno, V ^{[1
]}

Germano, P ^{[1
]}

Mavilia, C ^{[1
]}

Maggi, E ^{[1
]}

Romagnani, S ^{[1
]}

机构：

[1] UNIV FLORENCE,IST CLIN MED 3,CATTEDRA IMMUNOL CLIN & ALLERGOL,SERV IMMUNOALLERGOL,I-50134 FLORENCE,ITALY

来源：

FASEB JOURNAL | 1996年 / 10卷 / 07期

关键词：

membrane LAG-3; soluble LAG-3; human Th1/Th2 cells; IL-4; IFN-gamma;

D O I：

10.1096/fasebj.10.7.8635694

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The lymphocyte activation gene (LAG)-3 is a member of the immunoglobulin superfamily that is selectively transcribed in human activated T and NK cells, In this wort, the possibility that LAG-3 expression by human CD4(+) T cells was preferentially related to one or another phenotype of cytokine secretion was investigated, Surface LAG-3 expression correlated with IFN-gamma, but not IL-4, production in antigen-stimulated T cells and it was upregulated by IL-12, Most activated CD4(+) T cell clones with established Th1 or Th0 profiles of cytokine secretion expressed LAG-3 on their surface, whereas the great majority of Th2 clones showed neither surface LAG-3 nor LAG-3 mRNA expression, After activation, the majority of CD4+ T cell clones also released soluble LAG-3-related peptides, and such a release correlated positively with the production of IFN-gamma and inversely with the production of IL-4. Thus, LAG-3 expression by activated CD4+ human T cells appear to be preferentially associated with the differentiation/activation pathway leading to the production of IFN-gamma.

引用

页码：769 / 776

页数：8

共 32 条

[1] CHARACTERIZATION OF THE LYMPHOCYTE-ACTIVATION GENE 3-ENCODED PROTEIN - A NEW LIGAND FOR HUMAN-LEUKOCYTE ANTIGEN CLASS-II ANTIGENS [J].