Critical analysis of radioiodination techniques for micro and macro organic molecules

被引：34
作者：
Mushtaq, Sajid [1 ,2 ]
Jeon, Jongho [1 ,2 ]
Shaheen, Aqeela [3 ]
Jang, Beom Su [1 ,2 ]
Park, Sang Hyun [1 ,2 ]
机构：
[1] Korea Atom Energy Res Inst, Div Biotechnol, Jeongeup 580185, Jeonbuk, South Korea
[2] Korea Univ Sci & Technol, Dept Radiat Biotechnol & Appl Radioisotope Sci, Daejeon 305350, South Korea
[3] Islamia Univ Bahawalpur, Dept Chem, Fac Sci, Bahawalpur 63100, Pakistan
来源：
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY | 2016年 / 309卷 / 02期
基金：
新加坡国家研究基金会;
关键词：
Radioiodination Chloramine-T; Iodogen; N-halosuccinimides; Radioiodo-desilylation; NCA ELECTROPHILIC RADIOIODINATION; LOW-DENSITY-LIPOPROTEIN; N-SUCCINIMIDYL; BIOLOGICAL EVALUATION; IN-VITRO; PROSTHETIC RADIOIODINATION; RADIO-IODINATION; BIODISTRIBUTION; SPECT; ANTIBODY;
D O I：
10.1007/s10967-015-4679-z
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A variety of radioiodination methods is available in the literature depending upon the nature of organic compound to be labeled, however only few can completely fulfill manufacturing requirements.Ideally a selected method should be one which offers maximum benefits like regioselectivity, minimum reaction steps, minimum reaction time, high radiochemical yield and high specific activity. In this review radioiodination techniques were critically analyzed. Advantages, drawbacks, possible mode of action and special reaction conditions required to get high radiochemical yield were taken into account. The influence of iodine introduction on physicochemical properties, in vivo or in vitro pharmacological properties of pharmaceutical due to increase of lipophilicity were discussed along with examples.
引用
收藏
页码：859 / 889
页数：31
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