A prospective analysis of blood donation history and risk of non-Hodgkin lymphoma

被引：5

作者：

Ishii, Kazusa ^{[1
]}

Birmann, Brenda M. ^{[2
,3
]}

Zhang, Xuehong ^{[2
,3
]}

Giovannucci, Edward ^{[2
,3
,4
,5
]}

Bertrand, Kimberly A. ^{[2
,3
]}

机构：

[1] NHLBI, Hematol Branch, NIH, Bethesda, MD 20892 USA

[2] Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 181 Longwood Ave, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, 181 Longwood Ave, Boston, MA 02115 USA

[4] Harvard Univ, TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA

[5] Harvard Univ, TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA

来源：

LEUKEMIA & LYMPHOMA | 2016年 / 57卷 / 06期

关键词：

Blood donation; non-Hodgkin lymphoma; epidemiology; risk; KILLER-CELL ACTIVITY; EPIDEMIOLOGIC RESEARCH; CANCER; DONORS; NEOPLASMS; CYTOKINES; PLASMAPHERESIS; CLASSIFICATION; ASSOCIATION; IMMUNITY;

D O I：

10.3109/10428194.2015.1091928

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Blood donation may influence subsequent NHL development via temporary immune system alterations. To test the hypothesis that frequent blood donation is associated with an increased risk of NHL and its most common histologic subtypes, this study followed 36 576 men in the Health Professionals Follow-up Study (HPFS), who provided information on frequency of blood donation in the past 30 years in 1992. This study confirmed 544 incident cases of NHL through 2010. Cox proportional hazards regression was used to calculate hazards ratios (HR) and 95% CI for the risk of all NHL and major NHL histologic subtypes associated with number of blood donations. In this prospective study, there was no significant evidence of an association between blood donation frequency and incidence of NHL (age-adjusted HR=1.26, 95% CI=0.94-1.68, comparing>20 donations vs 0 donations over 30 years, p for trend=0.18) or of any major NHL subtypes.

引用

页码：1423 / 1428

页数：6

共 35 条

[1] The non-Hodgkin lymphomas: A review of the epidemiologic literature [J].