Identification of luteolin 7-O-β-D-glucuronide from Cirsium japonicum and its anti-inflammatory mechanism

被引：34

作者：

Ma, Qin ^{[1
]}

Jiang, Jian-Guo ^{[1
]}

Zhang, Xi-Mei ^{[1
]}

Zhu, Wei ^{[2
]}

机构：

[1] South China Univ Technol, Coll Food & Bioengn, Guangzhou 510640, Guangdong, Peoples R China

[2] Guangzhou Univ Chinese Med, Affiliated Hosp 2, Guangzhou 510120, Guangdong, Peoples R China

来源：

JOURNAL OF FUNCTIONAL FOODS | 2018年 / 46卷

关键词：

Cirsium japonicurn; Flavonoids; Luteolin-7-O-beta-D-glucuronide; Anti-inflammation; Macrophages; RUBUS-CHINGII HU; D-GALACTOSAMINE; KAPPA-B; MACROPHAGES; INFLAMMATION; ANTIOXIDANT; CYCLOOXYGENASE-2; CONSTITUENTS; ACTIVATION; FLAVONOIDS;

D O I：

10.1016/j.jff.2018.05.014

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Cirsium japonicum DC is listed as a health food in China used for cooling blood and hemostasis. The aim of this study was to identify its active components with anti-inflammation activity. C. japonicum was extract with 70% ethanol, and then loaded on a macroporous resin column chromatography to get five fractions. Results showed that fraction CJ-50 exhibited the best anti-inflammation effect. Six compounds, luteolin-7-O-beta-D-glucuronide (LG), luteolin-7-O-beta-D-glucuronide methyl ester, apigenin-7-O-beta-D-glucuronide (AG), linarin, apigenin-7-O-beta-D-glucuronide methyl ester, and pectolinarin, were isolated and identified from the fraction. The six flavonoid compounds exhibited different degree of anti-inflammatory activity, among which LG and AG showed stronger activity than others. Further research showed that LG can inhibit the NO and pro-inflammatory cytokines production, likely resulting from inhibiting the phosphorylation of JNK. Taken together, these results suggest that LG may be therapeutic candidate for anti-inflammation activity of C. japonicum as well as a dietary complement for health promotion.

引用

页码：521 / 528

页数：8

共 33 条

[1]

Feng Wei-sheng, 2007, Yaoxue Xuebao, V42, P625

[2] Development of Monocytes, Macrophages, and Dendritic Cells [J].

Geissmann, Frederic ;

Manz, Markus G. ;

Jung, Steffen ;

Sieweke, Michael H. ;

Merad, Miriam ;

Ley, Klaus .

SCIENCE, 2010, 327 (5966) :656-661

[3] Alternative Activation of Macrophages: Mechanism and Functions [J].

Gordon, Siamon ;

Martinez, Fernando O. .

IMMUNITY, 2010, 32 (05) :593-604

[4] Luteolin and luteolin-7-O-glucoside from dandelion flower suppress iNOS and COX-2 in RAW264.7 cells [J].

Hu, C ;

Kitts, DD .

MOLECULAR AND CELLULAR BIOCHEMISTRY, 2004, 265 (1-2) :107-113

[5] Functional Analyses on Antioxidant, Anti-inflammatory, and Antiproliferative Effects of Extracts and Compounds from Ilex latifolia Thunb., a Chinese Bitter Tea [J].

Hu, Ting ;

He, Xiao-Wei ;

Jiang, Jian-Guo .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2014, 62 (34) :8608-8615

[6] Apigenin-7-O-β-D-glucuronide inhibits LPS-nduced inflammation through the inactivation of AP-1 and MAPK signaling pathways in RAW 264.7 macrophages and protects mice against endotoxin shock [J].

Hu, Weicheng ;

Wang, Xinfeng ;

Wu, Lei ;

Shen, Ting ;

Ji, Lilian ;

Zhao, Xihong ;

Si, Chuan-Ling ;

Jiang, Yunyao ;

Wang, Gongcheng .

FOOD & FUNCTION, 2016, 7 (02) :1002-1013

[7] Comparison of the sedative and hypnotic effects of flavonoids, saponins, and polysaccharides extracted from Semen Ziziphus jujube [J].

Jiang, Jian-Guo ;

Huang, Xiao-Juan ;

Chen, Jian ;

Lin, Qing-Sheng .

NATURAL PRODUCT RESEARCH, 2007, 21 (04) :310-320

[8] Anti-inflammatory activity of Korean thistle Cirsium maackii and its major flavonoid, luteolin 5-O-glucoside [J].

Jung, Hyun Ah ;

Jin, Seong Eun ;

Min, Byung-Sun ;

Kim, Byung-Woo ;

Choi, Jae Sue .

FOOD AND CHEMICAL TOXICOLOGY, 2012, 50 (06) :2171-2179

[9] Recent Advances on the Roles of NO in Cancer and Chronic Inflammatory Disorders [J].

Kanwar, Jagat R. ;

Kanwar, Rupinder K. ;

Burrow, Hannah ;

Baratchi, Sara .

CURRENT MEDICINAL CHEMISTRY, 2009, 16 (19) :2373-2394

[10]

Kershenobich Stalnikowitz D., 2003, ANN HEPATOL, V2, P159, DOI 10.1016/S1665-2681(19

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