共 36 条
Differential requirements for Alix and ESCRT-III in cytokinesis and HIV-1 release
被引:174
作者:

Carlton, Jez G.
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll London, Sch Med, Dept Infect Dis, London SE1 9RT, England Kings Coll London, Sch Med, Dept Infect Dis, London SE1 9RT, England

Agromayor, Monica
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll London, Sch Med, Dept Infect Dis, London SE1 9RT, England Kings Coll London, Sch Med, Dept Infect Dis, London SE1 9RT, England

Martin-Serrano, Juan
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll London, Sch Med, Dept Infect Dis, London SE1 9RT, England Kings Coll London, Sch Med, Dept Infect Dis, London SE1 9RT, England
机构:
[1] Kings Coll London, Sch Med, Dept Infect Dis, London SE1 9RT, England
来源:
基金:
英国医学研究理事会;
关键词:
late domain;
viral budding;
Class E VPS;
L-domain;
cell division;
D O I:
10.1073/pnas.0802008105
中图分类号:
O [数理科学和化学];
P [天文学、地球科学];
Q [生物科学];
N [自然科学总论];
学科分类号:
07 ;
0710 ;
09 ;
摘要:
The ESCRT machinery functions in topologically equivalent membrane fission events, namely multivesicular body formation, the terminal stages of cytokinesis and HIV-1 release. Here, we show that the ESCRT-III-binding protein Alix is recruited to the midbody of dividing cells through binding Cep55 via an evolutionarily conserved peptide. Disruption of Cep55/Alix/ESCRT-III interactions causes formation of aberrant midbodies and cytokinetic failure, demonstrating an essential role for these proteins in midbody morphology and cell division. We also show that the C terminus of Alix encodes a multimerization activity that is essential for its function in Alix-dependent HIV-1 release and for interaction with Tsg 101. Last, we demonstrate that overexpression of Chmp4b and Chmp4c differentially inhibits HIV-1 release and cytokinesis, suggesting possible reasons for gene expansion within the mammalian Class E VPS pathway.
引用
收藏
页码:10541 / 10546
页数:6
相关论文
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