Atovaquone-proguanil resistance in imported falciparum malaria in a young child

被引：14
作者：
Rose, Gregory W. [1 ]
Suh, Kathryn N. [1 ]
Kain, Kevin C. [2 ]
Le Saux, Nicole [3 ]
McCarthy, Anne E. [1 ]
机构：
[1] Ottawa Hosp, Div Infect Dis, Ottawa, ON, Canada
[2] Univ Toronto, Toronto Gen Hosp, McLaughlin Rotman Ctr Global Hlth, Trop Dis Unit, Toronto, ON M5G 1L7, Canada
[3] Childrens Hosp Eastern Ontario, Div Infect Dis, Ottawa, ON K1H 8L1, Canada
来源：
PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2008年 / 27卷 / 06期
关键词：
plasmodium falciparum; resistance; cytochrome b; atovaquone-proguanil; malarone;
D O I：
10.1097/INF.0b013e318167918d
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We discuss a case of atovaquone-proguanil treatment failure in a child from Mozambique, recently arrived in North America. Four weeks after completing therapy, symptomatic parasitemia recurred, caused by Plasmodium falciparum parasites bearing a Tyr268Ser mutation in cytochrome b. We review the literature concerning atovaquone-proguanil resistance, and emphasize the importance of follow-up and consideration of resistance where patients have relapsed symptoms.
引用
收藏
页码：567 / 569
页数：3
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