Nanoscale CaH2 materials for synergistic hydrogen-immune cancer therapy

被引：147

作者：

Gong, Fei ^{[1
]}

Xu, Jiachen ^{[2
]}

Liu, Bo ^{[1
]}

Yang, Nailin ^{[1
]}

Cheng, Liang ^{[1
]}

Huang, Peng ^{[2
]}

Wang, Chunjie ^{[1
]}

Chen, Qian ^{[1
]}

Ni, Caifang ^{[2
]}

Liu, Zhuang ^{[1
]}

机构：

[1] Soochow Univ, Inst Funct Nano & Soft Mat FUNSOM, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Suzhou 215123, Peoples R China

[2] Soochow Univ, Dept Intervent Radiol, Affiliated Hosp 1, Suzhou 215006, Peoples R China

来源：

CHEM | 2022年 / 8卷 / 01期

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

CELL-DEATH; HEPATOCELLULAR-CARCINOMA; F-18-FDG PET/CT; CALCIUM; CHEMOEMBOLIZATION; OVERLOAD;

D O I：

10.1016/j.chempr.2021.11.020

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein, we prepared CaH2 nanoparticles through liquid-phase exfoliation and first applied them as an antitumor therapeutic agent. Being dispersed in low-molecular-weight polyethylene glycol (PEG) and injected into the tumor, nano-CaH2 would react with water to generate abundant hydrogen gas (H-2), calcium ions (Ca2+), and hydroxyl ions (OH-), enabling hydrogen therapy, tumor calcification, and neutralization of acidic tumor microenvironment (TME), respectively. The injectable nano-CaH2 dispersion could lead to significant tumor growth inhibition. In addition, the local nano-CaH2-induced tumor cell apoptosis and TME modulation would activate the immune system and promote tumor infiltration of immune cells, which, working together with immune checkpoint blockade, could elicit robust immune responses to inhibit abscopal distant tumors without direct nano-CaH2 injection. Furthermore, nano-CaH2 could be dispersed in lipiodol to obtain CaH2-lipiodol dispersion for interventional transarterial embolization (TAE) therapy, and they showed obviously improved TAE therapeutic outcome on orthotopic rabbit liver cancer model compared with lipiodol alone.

引用

页码：268 / +

页数：20

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