A Mitochondrial Surface-Specific Fluorescent Probe Activated by Bioconversion

被引：55

作者：

Kawazoe, Yoshinori ^{[1
]}

Shimogawa, Hiroki ^{[1
]}

Sato, Ayato ^{[1
]}

Uesugi, Motonari ^{[1
,2
]}

机构：

[1] Kyoto Univ, Inst Chem Res, Kyoto 6110011, Japan

[2] Kyoto Univ, Inst Integrated Cell Mat Sci, Kyoto 6110011, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 24期

关键词：

bioconversion; cyclization; fluorescent probes; live-cell imaging; mitochondria; CELLS; APOPTOSIS; DISCOVERY;

D O I：

10.1002/anie.201100935

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Cell-based image screening of 12000 small molecules with aromatic groups was carried out, and 31 were identified as having potential as fluorescent probes for living cells. One candidate is the first fluorescent probe that specifically stains mitochondrial surfaces. Spectroscopic analyses indicate that the molecule undergoes bioconversion to be fluorescent within cells. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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收藏

页码：5478 / 5481

页数：4

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