Hyaluronic Acid Stabilized Doxorubicin Nano-Precipitations for Osteosarcoma Treatment

被引：0
作者：
Huang, Mouzhang [1 ]
Zeng, Limei [2 ]
Zhu, Rongping [1 ]
Chen, Gongqun [1 ]
Wu, Haijian [1 ]
Fan, Bin [1 ]
Liu, Changtie [1 ]
Guo, Bowen [1 ]
Zhong, Hongfa [1 ]
机构：
[1] Nanchang Univ, Affiliated Ganzhou Hosp, Ganzhou Peoples Hosp, Dept Orthoped Surg, Ganzhou 341000, Jiangxi, Peoples R China
[2] Gannan Med Univ, Ganzhou 341000, Jiangxi, Peoples R China
来源：
JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING | 2022年 / 12卷 / 03期
关键词：
Hyaluronic Acid; Doxorubicin; Nano-Precipitations; Osteosarcoma; DELIVERY; NANOPARTICLES; CELLS;
D O I：
10.1166/jbt.2022.2935
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Doxorubicin (Dox) is a wide-spectrum drug to treat different kinds of cancers. However, in clinical practice, Dox usually showed untargeted distributions to the other organs, which can cause serious side effects, such as cardiotoxity. Herein, the formulation of Dox into nanoparticles is critical to enhance its distribution to tumors. Herein, we used polysaccharide, hyaluronic acid, to stabilize the Dox to form nano-precipitations (PD NPs) for the therapy of osteosarcoma. The PD NPs showed enhanced drug accumulation to tumor cells and realized better anticancer effects than free drugs.
引用
收藏
页码：500 / 505
页数：6
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