Genetic variations of interleukin-1 and-6 genes and risk of cervical intraepithelial neoplasia

被引：28

作者：

Grimm, Christoph ^{[1
]}

Watrowski, Rafal ^{[1
]}

Baumuehlner, Konstantin ^{[1
]}

Natter, Camilla ^{[1
]}

Tong, Dan ^{[1
]}

Wolf, Andrea ^{[1
]}

Zeillinger, Robert ^{[1
]}

Leodolter, Sepp ^{[1
]}

Reinthaller, Alexander ^{[1
]}

Hefler, Lukas ^{[2
]}

机构：

[1] Med Univ Vienna, Ctr Comprehens Canc, Dept Gynecol & Gynecol Oncol, A-1090 Vienna, Austria

[2] Karl Landsteiner Inst Gynecol Surg & Oncol, Vienna, Austria

来源：

GYNECOLOGIC ONCOLOGY | 2011年 / 121卷 / 03期

关键词：

Interleukin-1; Interleukin-6; Gene; Polymorphism; CIN; Cervical intraepithelial neoplasia risk; HUMAN-PAPILLOMAVIRUS INFECTION; RECEPTOR ANTAGONIST; PROMOTER POLYMORPHISM; CARCINOMA CELLS; TUMOR-GROWTH; CANCER; EXPRESSION; DISEASE; IL-1RA; IL-6;

D O I：

10.1016/j.ygyno.2011.02.019

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Objective. To evaluate the association between five interleukin-1 (IL-1) and -6 gene polymorphisms and risk of high grade cervical intraepithelial neoplasia (CIN 2-3). Methods. This case-control study investigates five common IL-1 and IL-6 gene polymorphisms in 131 women with CIN 2-3 and 209 controls by pyrosequencing and polymerase chain reaction. Associations between gene polymorphisms and risk of CIN 2-3 are analysed by univariate and multivariable models. Their combined effect on the risk of CIN is evaluated by haplotype analysis. Results. In a multivariable regression model IL1A 889 (odds ratio 0.3 [95% confidence interval 0.1-0.8], p = 0.01) and smoking (4.0 [1.7-9.1] p = 0.001) are independently associated with the risk of high grade CIN. Haplotype analysis does not reveal any high-risk combinations for the susceptibility of CIN. Conclusion. The single nucleotide polymorphism IL1A - 889 is independently associated with risk of high grade CIN. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：537 / 541

页数：5

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