The potential neuromodulatory impact of subthalamic nucleus deep brain stimulation on Parkinson's disease progression

被引：1

作者：

Szlufik, Stanislaw ^{[1
]}

Duszynska-Lysak, Karolina ^{[1
]}

Przybyszewski, Andrzej ^{[2
]}

Laskowska-Levy, Ilona ^{[3
,4
]}

Drzewinska, Agnieszka ^{[1
]}

Dutkiewicz, Justyna ^{[1
]}

Mandat, Tomasz ^{[5
]}

Habela, Piotr ^{[2
]}

Koziorowski, Dariusz ^{[1
]}

机构：

[1] Med Univ Warsaw, Fac Hlth Sci, Dept Neurol, Kondratowicza 8, PL-03242 Warsaw, Poland

[2] Polish Japanese Acad Informat Technol, Fac Informat Technol, Warsaw, Poland

[3] Univ Econ & Human Sci, Dept Cognit Psychol, Mus Performance & Brain Lab, Warsaw, Poland

[4] Nowowiejski Hosp, Psychotherapy Ctr, Daily Dept Neurot Disorders 13, Warsaw, Poland

[5] Maria Sklodowska Curie Mem Oncol Ctr, Dept Neurosurg, Warsaw, Poland

来源：

JOURNAL OF CLINICAL NEUROSCIENCE | 2020年 / 73卷

关键词：

Parkinson's disease; Deep brain stimulation; Neuroprotection; Neuromodulatory; DBS; RANDOMIZED-TRIAL; MEDICAL THERAPY; SURVIVAL;

D O I：

10.1016/j.jocn.2019.12.059

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction: STN-DBS has been claimed to change progression symptoms in animal models of PD, but information is lacking about the possible neuromodulatory role of STN-DBS in humans. The aim of this prospective controlled study was to evaluate the long-term impact of STN-DBS on motor disabilities and cognitive impairment in PD patients in comparison to Best-Medical-Therapy (BMT) and Longterm-Post-Operative (POP) groups. Material and methods: Patients were divided into 3 groups: the BMT-group consisted of 20 patients treated only with pharmacotherapy, the DBS-group consisted of 20 PD patients who underwent bilateral STN-DBS (examined pre- and postoperatively) and the POP-group consisted of 14 long-term postoperative patients in median 30 month-time after DBS. UPDRS III scale was measured during 3 visits in 9 +/- 2 months periods (V1, V2, V3) in total-OFF phase. Cognitive assessment was performed during each visit in total-ON phase. Results: The comparable UPDRS III OFF gain was observed in both BMT-group and POP-group evaluations (p < 0.05). UPDRS III OFF results in DBS-group revealed significant UPDRS III OFF increase in Delta V2-V1 assessment (p < 0.05) with no significant UPDRS III OFF alteration in Delta V3-V2 DBS-group evaluation (p > 0.05). Cognitive assessment revealed significant alterations between DBS-group and BMT-group in working memory, executive functions and learning abilities (p < 0.05). Conclusions: The impact of STN-DBS on UPDRS III OFF score and cognitive alterations suggest its neuromodulatory role, mainly during the first 9-18 months after surgery. (C) 2019 Published by Elsevier Ltd.

引用

页码：150 / 154

页数：5

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