Oxazole-Based Compounds As Anticancer Agents

被引：51

作者：

Chiacchio, Maria A. ^{[1
]}

Lanza, Giuseppe ^{[1
]}

Chiacchio, Ugo ^{[1
]}

Giofre, Salvatore V. ^{[2
]}

Romeo, Roberto ^{[2
]}

Iannazzo, Daniela ^{[3
]}

Legnani, Laura ^{[1
,4
]}

机构：

[1] Univ Catania, Dipartimento Sci Farmaco, Vle Doria 6, I-95125 Catania, Italy

[2] Univ Messina, Dipartimento Sci Chim Biol Farmaceut & Ambientali, Via SS Annunziata, I-98168 Messina, Italy

[3] Univ Messina, Dipartimento Ingn, I-98166 Messina, Italy

[4] Univ Pavia, Dipartimento Chim, Via Taramelli 12, I-27100 Pavia, Italy

来源：

CURRENT MEDICINAL CHEMISTRY | 2019年 / 26卷 / 41期

关键词：

Oxazole; isoxazole; oxazoline; oxazolidine; anticancer activity; synthesis; STRUCTURE-BASED DESIGN; BIOLOGICAL EVALUATION; ISOXAZOLE DERIVATIVES; ANTITUMOR-ACTIVITY; CARBONYL-COMPOUNDS; DISCOVERY; INHIBITORS; ANALOGS; POTENT; OXAZOLIDINONES;

D O I：

10.2174/0929867326666181203130402

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Heterocyclic compounds represent a significant target for anti-cancer research and drug discovery, due to their structural and chemical diversity. Oxazoles, with oxygen and nitrogen atoms present in the core structure, enable various types of interactions with different enzymes and receptors, favoring the discovery of new drugs. Aim of this review is to describe the most recent reports on the use of oxazole-based compounds in anticancer research, with reference to the newly discovered iso/oxazole-based drugs, to their synthesis and to the evaluation of the most biologically active derivatives. The corresponding dehydrogenated derivatives, i.e. iso/oxazolines and iso/oxazolidines, are also reported.

引用

页码：7337 / 7371

页数：35

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