Preparation of fibril nuclei of beta-amyloid peptides in reverse micelles

被引：28

作者：

Lin, Yen-Ling ^{[1
]}

Cheng, Yu-Sheng ^{[1
]}

Ho, Cheng-I ^{[1
]}

Guo, Zhong-Hong ^{[1
]}

Huang, Shing-Jong ^{[2
]}

Org, Mai-Liis ^{[3
]}

Oss, Andres ^{[3
]}

Samoson, Ago ^{[3
]}

Chan, Jerry Chun Chung ^{[1
]}

机构：

[1] Natl Taiwan Univ, Dept Chem, 1,Sect 4,Roosevelt Rd, Taipei 10617, Taiwan

[2] Natl Taiwan Univ, Instrumentat Ctr, Taipei 10617, Taiwan

[3] Tallinn Univ Technol, Inst Hlth Technol, Akad 15A, Tallinn, Estonia

来源：

CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 74期

关键词：

SOLID-STATE NMR; A-BETA; STRUCTURAL POLYMORPHISM; 100; KHZ; ALZHEIMERS; PROTEIN; KINETICS; FIBRILLOGENESIS; PROTOFIBRILS; A-BETA(1-40);

D O I：

10.1039/c8cc05882b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report the preparation of protofibrils from oligomeric A(40) aggregates, which have been incubated under spatially constrained conditions. The molecular structure of the resultant protofibrils is highly homogeneous, suggesting that the phenomenon of structural polymorphism commonly observed in A(40) fibrils may be largely due to multiple nucleation events.

引用

页码：10459 / 10462

页数：4

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