Status of Free-Radical Oxidation and Proliferation Processes in Patients with Atopic Dermatitis and Lichen Planus

被引：24

作者：

Sapuntsova, S. G. ^{[2
]}

Lebed'ko, O. A. ^{[1
]}

Shchetkina, M. V. ^{[2
]}

Fleyshman, M. Yu. ^{[2
]}

Kozulin, E. A. ^{[2
]}

Timoshin, S. S. ^{[3
]}

机构：

[1] Russian Acad Med Sci, Siberian Div,Res Inst Maternal & Child Hlth Care, Khabarovsk Branch,Clin Diagnost Lab, Far Eastern Res Ctr Physiol & Pathol & Respirat, Moscow 109801, Russia

[2] Far Eastern State Med Univ, Minist Hlth Care & Social Dev Russian Federat, Dept Dermatol, Khabarovsk, Russia

[3] Far Eastern State Med Univ, Minist Hlth Care & Social Dev Russian Federat, Cent Res Lab, Khabarovsk, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2011年 / 150卷 / 06期

关键词：

free-radical oxidation; proliferation; lichen planus; apotic dermatitis; MAP KINASE; REDOX; STRESS;

D O I：

10.1007/s10517-011-1224-0

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We studied the status of proliferation processes (by Ki-67 expression) and biogenesis of free radicals (by chemiluminescence method) in skin biopsy specimens from patients with atopic dermatitis and lichen planus. The index of Ki-67-positive nuclei significantly (p<0.05) increased to 28.40 +/- 2.00% in patients with dermatitis and to 32.6 +/- 1.9% in patients with lichen planus vs. 8.65 +/- 1.31% in the reference sample. Decompensated accumulation of free-radical oxidation products and inhibition of detoxification systems in skin biopsy specimens indicate the development of local oxidative stress. After therapy consisting of two 10-day courses of thymodepressin injections (0.1%, 1.0 ml) over 30 days, normalization of epidermis proliferation was observed. Labeling index in atopic dermatitis and lichen planus significantly decreased (p<0.05) to 17.00 +/- 1.87 and 10.9 +/- 1.1%, respectively. The role of free radicals in the development of hyperregeneratory processes during dermatoses is discussed.

引用

页码：690 / 692

页数：3

共 12 条

[1] Arutyunyan AV, 2000, METHODS EVALUATION F
[2] Antioxidant activity, lipid peroxidation and skin diseases. What's new
Briganti, S
Picardo, M
[J]. JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2003, 17 (06) : 663 - 669
[3] The cell cycle is a redox cycle: Linking phase-specific targets to cell fate
Burhans, William C.
Heintz, Nicholas H.
[J]. FREE RADICAL BIOLOGY AND MEDICINE, 2009, 47 (09) : 1282 - 1293
[4] Recent advances towards understanding redox mechanisms in the activation of nuclear factor κB
Janssen-Heininger, YMW
Poynter, ME
Baeuerle, PA
[J]. FREE RADICAL BIOLOGY AND MEDICINE, 2000, 28 (09) : 1317 - 1327
[5] [Кашперова О.Г. Kashperova O.G.], 2009, [Клиническая дерматология и венерология, Klinicheskaya dermatologiya i venerologiya], P41
[6] KOROTKII NG, 2008, VESTN POSLEDIP MED O, P7
[7] Intracellular redox status and oxidative stress:: implications for cell proliferation, apoptosis, and carcinogenesis
Mates, Jose M.
Segura, Juan A.
Alonso, Francisco J.
Marquez, Javier
[J]. ARCHIVES OF TOXICOLOGY, 2008, 82 (05) : 273 - 299
[8] Redox control of cell fate by MAP kinase: physiological roles of ASK1-MAP kinase pathway in stress signaling
Matsuzawa, Atsushi
Ichijo, Hidenori
[J]. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2008, 1780 (11): : 1325 - 1336
[9] Menshikova E.B., 2008, OXIDATIVE STRESS PAT
[10] Epidermocyte nuclear-nucleolar system in atopic dermatitis and lichen planus
Sapuntsova, S. G.
Tsygankov, V. I.
Simkatcheva, M. V.
Timoshin, S. S.
[J]. BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2007, 144 (03) : 376 - 378

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