Role of Histaminergic System in Blood-Brain Barrier Dysfunction Associated with Neurological Disorders

被引：24
作者：
Banuelos-Cabrera, Ivette [1 ]
Valle-Dorado, Maria Guadalupe [1 ]
Aldana, Blanca Irene [1 ]
Orozco-Suarez, Sandra Adela [2 ]
Rocha, Luisa [1 ]
机构：
[1] Ctr Res & Adv Studies, Dept Pharmacobiol, Mexico City 14330, DF, Mexico
[2] Natl Med Ctr, Unit Med Res Neurol Dis, Mexico City, DF, Mexico
来源：
ARCHIVES OF MEDICAL RESEARCH | 2014年 / 45卷 / 08期
关键词：
Histamine; Blood-brain barrier; Mast cells; Neuroinflammation; Neurological disorders; MAST-CELL DEGRANULATION; ASTROCYTE-ENDOTHELIAL INTERACTIONS; VASOACTIVE-INTESTINAL-PEPTIDE; INDUCED STATUS EPILEPTICUS; L-HISTIDINE DECARBOXYLASE; TIGHT JUNCTION PROTEINS; RAT-BRAIN; GROWTH-FACTOR; H-3; RECEPTOR; TNF-ALPHA;
D O I：
10.1016/j.arcmed.2014.11.010
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Blood-brain barrier (BBB) disruption has been associated with several acute and chronic brain disorders such as Alzheimer's disease, Parkinson's disease and epilepsy. This represents a critical situation because damaged integrity of the BBB is related to the influx of immune mediators, plasma proteins and other outside elements from blood to the central nervous system (CNS) that may trigger a cascade of events that leads to neuroinflammation. In this review, evidence that mast cells and the release of factors such as histamine play an ithportant role in the neuroinflammatory process associated with brain disorders such as Alzheimer's disease, Parkinson's disease and epilepsy is presented. (C) 2014 IMSS. Published by Elsevier Inc.
引用
收藏
页码：677 / 686
页数：10
相关论文
共 161 条
[1]   Structure and function of the blood-brain barrier [J].
Abbott, N. Joan ;
Patabendige, Adjanie A. K. ;
Dolman, Diana E. M. ;
Yusof, Siti R. ;
Begley, David J. .
NEUROBIOLOGY OF DISEASE, 2010, 37 (01) :13-25
[2]   Astrocyte-endothelial interactions at the blood-brain barrier [J].
Abbott, NJ ;
Rönnbäck, L ;
Hansson, E .
NATURE REVIEWS NEUROSCIENCE, 2006, 7 (01) :41-53
[3]   Astrocyte-endothelial interactions and blood-brain barrier permeability [J].
Abbott, NJ .
JOURNAL OF ANATOMY, 2002, 200 (06) :629-638
[4]   Cytokines and acute neurodegeneration [J].
Allan, SM ;
Rothwell, NJ .
NATURE REVIEWS NEUROSCIENCE, 2001, 2 (10) :734-744
[5]   IL-1β, IL-6 and TNF-α and outcomes of neonatal hypoxic ischemic encephalopathy [J].
Aly, H ;
Khashaba, MT ;
El-Ayouty, M ;
El-Sayed, O ;
Hasanein, BM .
BRAIN & DEVELOPMENT, 2006, 28 (03) :178-182
[6]   Inflammation in epilepsy: Clinical observations [J].
Aronica, Eleonora ;
Crino, Peter B. .
EPILEPSIA, 2011, 52 :26-32
[7]   Constitutive activity of the histamine H3 receptor [J].
Arrang, Jean-Michel ;
Morisset, Severine ;
Gbahou, Florence .
TRENDS IN PHARMACOLOGICAL SCIENCES, 2007, 28 (07) :350-357
[8]   AUTO-INHIBITION OF BRAIN HISTAMINE-RELEASE MEDIATED BY A NOVEL CLASS (H-3) OF HISTAMINE-RECEPTOR [J].
ARRANG, JM ;
GARBARG, M ;
SCHWARTZ, JC .
NATURE, 1983, 302 (5911) :832-837
[9]   Control of synaptic strength by glial TNFα [J].
Beattie, EC ;
Stellwagen, D ;
Morishita, W ;
Bresnahan, JC ;
Ha, BK ;
Von Zastrow, M ;
Beattie, MS ;
Malenka, RC .
SCIENCE, 2002, 295 (5563) :2282-2285
[10]   Stroke induces histamine accumulation and mast cell degranulation in the neonatal rat brain [J].
Biran, V. ;
Cochois, V. ;
Karroubi, A. ;
Arrang, J. M. ;
Charriaut-Marlangue, C. ;
Heron, A. .
BRAIN PATHOLOGY, 2008, 18 (01) :1-9
12345678910