Resting and activated endothelial cells are increased in the peripheral blood of cancer patients

被引：347

作者：

Mancuso, P

Burlini, A

Pruneri, G

Goldhirsch, A

Martinelli, G

Bertolini, F

机构：

[1] European Inst Oncol, Div Hematol Oncol, I-20141 Milan, Italy

[2] European Inst Oncol, Div Pathol Lab Med, I-20141 Milan, Italy

[3] European Inst Oncol, Div Med Oncol, I-20141 Milan, Italy

来源：

BLOOD | 2001年 / 97卷 / 11期

关键词：

D O I：

10.1182/blood.V97.11.3658

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Circulating endothelial cells (CECs) were enumerated in 20 healthy controls and 76 newly diagnosed cancer patients by means of a-color flow cytometry. In breast cancer (n = 46) and lymphoma (n = 30) patients, both resting and activated CECs were increased by 5-fold (P < .0008 vs control). CECs significantly correlated with plasma levels of vascular cell adhesion molecule-1 and vascular endothelial growth factor. Resting and activated CECs were similar to healthy controls in 7 lymphoma patients achieving complete remission after chemotherapy, and activated CECs were found to decrease in 13 breast cancer patients evaluated before and 24 hours after quadrantectomy.

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页码：3658 / 3661

页数：4

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