Retinal determination genes function along with cell-cell signals to regulate Drosophila eye development

被引:12
作者
Baker, Nicholas E. [1 ,2 ,3 ]
Firth, Lucy C. [1 ]
机构
[1] Albert Einstein Coll Med, Dept Genet, Bronx, NY 10467 USA
[2] Albert Einstein Coll Med, Dept Opthalmol & Visual Sci, Bronx, NY 10467 USA
[3] Albert Einstein Coll Med, Dept Dev & Mol Biol, Bronx, NY 10467 USA
关键词
cell-cell signal; Drosophila eye; eyeless; positional information; retinal determination gene; SINE-OCULIS; MORPHOGENETIC FURROW; PATTERN-FORMATION; HEDGEHOG; EYELESS; SPECIFICATION; EXPRESSION; SELECTOR; PROTEINS; ABSENT;
D O I
10.1002/bies.201000131
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
It is thought that retinal determination (RD) gene products define the response made to cell-cell signals in the field of eye development by binding to enhancers of genes that are also regulated by cell-cell signaling pathways. In Drosophila, RD genes, including eyeless, teashirt, eyes absent, dachsous, and sine oculis, are required for normal eye development and can induce ectopic eyes when mis-expressed. Characterization of the enhancers responsible for eye expression of the hedgehog, shaven, and atonal genes, as well as the dynamics of RD gene expression themselves, now suggest a multilayered network whereby transcriptional regulation by either RD genes or cell-cell signaling pathways can sometimes be indirect and mediated by other transcription factor intermediates. In this updated view of the interaction between extracellular information and cell intrinsic programs during development, regulation of individual genes might sometimes be several steps removed from either the RD genes or the cell-cell signaling pathways that nevertheless govern their expression.
引用
收藏
页码:538 / 546
页数:9
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