Invasive Candidiasis in Liver Transplant Recipients: a Review

被引：0

作者：

Sigler, Rachel ^{[1
]}

Aslam, Saima ^{[1
]}

机构：

[1] Univ Calif San Diego, Div Infect Dis & Global Publ Hlth, 4510 Execut Dr,MC7745, La Jolla, CA 92021 USA

来源：

CURRENT FUNGAL INFECTION REPORTS | 2021年 / 15卷 / 04期

关键词：

Liver transplant; Candida; Infection; Solid organ transplant; Invasive fungal infection; Fluconazole; T2; MAGNETIC-RESONANCE; FUNGAL-INFECTIONS; SOLID-ORGAN; ANTIFUNGAL PROPHYLAXIS; RISK-FACTORS; DOUBLE-BLIND; FLUCONAZOLE; AURIS; CANDIDEMIA; MANAGEMENT;

D O I：

10.1007/s12281-021-00426-6

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Purpose of Review This review summarizes the literature on invasive candidiasis (IC) in liver transplant recipients (LTRs) regarding diagnostic strategies, treatment, and prophylaxis. Recent Findings Recent literature on IC has expanded and refined definitions of risk factors for IC in LTRs. We discuss increasing rates of resistance among candida species and new antifungals. Diagnostic modalities continue to decrease time to initiation of empiric antifungals, which may impact outcomes. Summary A well-documented host of risk factors for IC may allow for targeted prophylaxis, while minimizing exposure to antifungal medications. Further research on minimum effective duration of treatment and prophylaxis is needed to combat resistance.

引用

页码：151 / 161

页数：11

共 82 条

[1] The epidemiology and outcomes of invasive Candida infections among organ transplant recipients in the United States: results of the Transplant-Associated Infection Surveillance Network (TRANSNET) [J].

Andes, David R. ;

Safdar, Nasia ;

Baddley, John W. ;

Alexander, Barbara ;

Brumble, Lisa ;

Freifeld, Allison ;

Hadley, Susan ;

Herwaldt, Loreen ;

Kauffman, Carol ;

Lyon, G. Marshall ;

Morrison, Vicki ;

Patterson, Thomas ;

Perl, Trish ;

Walker, Randall ;

Hess, Tim ;

Chiller, Tom ;

Pappas, Peter G. .

TRANSPLANT INFECTIOUS DISEASE, 2016, 18 (06) :921-931

[2] Candida infections in solid organ transplantation: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice [J].

Aslam, Saima ;

Rotstein, Coleman .

CLINICAL TRANSPLANTATION, 2019, 33 (09)

[3] PCR Diagnosis of Invasive Candidiasis: Systematic Review and Meta-Analysis [J].

Avni, Tomer ;

Leibovici, Leonard ;

Paul, Mical .

JOURNAL OF CLINICAL MICROBIOLOGY, 2011, 49 (02) :665-670

[4] Donor-Derived Transmission of Candida auris During Lung Transplantation [J].

Azar, Marwan M. ;

Turbett, Sarah E. ;

Fishman, Jay A. ;

Pierce, Virginia M. .

CLINICAL INFECTIOUS DISEASES, 2017, 65 (06) :1040-1042

[5] Incidence and outcome of invasive candidiasis in intensive care units (ICUs) in Europe: results of the EUCANDICU project [J].

Bassetti, Matteo ;

Giacobbe, Daniele R. ;

Vena, Antonio ;

Trucchi, Cecilia ;

Ansaldi, Filippo ;

Antonelli, Massimo ;

Adamkova, Vaclava ;

Alicino, Cristiano ;

Almyroudi, Maria-Panagiota ;

Atchade, Enora ;

Azzini, Anna M. ;

Carannante, Novella ;

Carnelutti, Alessia ;

Corcione, Silvia ;

Cortegiani, Andrea ;

Dimopoulos, George ;

Dubler, Simon ;

Garcia-Garmendia, Jose L. ;

Girardis, Massimo ;

Cornely, Oliver A. ;

Ianniruberto, Stefano ;

Kullberg, Bart Jan ;

Lagrou, Katrien ;

Le Bihan, Clement ;

Luzzati, Roberto ;

Malbrain, Manu L. N. G. ;

Merelli, Maria ;

Marques, Ana J. ;

Martin-Loeches, Ignacio ;

Mesini, Alessio ;

Paiva, Jose-Artur ;

Peghin, Maddalena ;

Raineri, Santi Maurizio ;

Rautemaa-Richardson, Riina ;

Schouten, Jeroen ;

Brugnaro, Pierluigi ;

Spapen, Herbert ;

Tasioudis, Polychronis ;

Timsit, Jean-Francois ;

Tisa, Valentino ;

Tumbarello, Mario ;

van den Berg, Charlotte H. S. B. ;

Veber, Benoit ;

Venditti, Mario ;

Voiriot, Guillaume ;

Wauters, Joost ;

Montravers, Philippe .

CRITICAL CARE, 2019, 23 (1)

[6]

Bassetti M, 2017, TRANSPLANT DIRECT, V3, DOI 10.1097/TXD.0000000000000673

[7] Infectious agents after liver transplant: etiology, timeline and patients' cell-mediated immunity responses [J].

Chiereghin, Angela ;

Petrisli, Evangelia ;

Ravaioli, Matteo ;

Morelli, Maria Cristina ;

Turello, Gabriele ;

Squarzoni, Diego ;

Piccirilli, Giulia ;

Ambretti, Simone ;

Gabrielli, Liliana ;

Pinna, Antonio Daniele ;

Landini, Maria Paola ;

Lazzarotto, Tiziana .

MEDICAL MICROBIOLOGY AND IMMUNOLOGY, 2017, 206 (01) :63-71

[8] Multidrug-resistant endemic clonal strain of Candida auris in India [J].

Chowdhary, A. ;

Kumar, V. Anil ;

Sharma, C. ;

Prakash, A. ;

Agarwal, K. ;

Babu, R. ;

Dinesh, K. R. ;

Karim, S. ;

Singh, S. K. ;

Hagen, F. ;

Meis, J. F. .

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 2014, 33 (06) :919-926

[9] Diagnosing Invasive Candidiasis [J].

Clancy, Cornelius J. ;

Nguyen, M. Hong .

JOURNAL OF CLINICAL MICROBIOLOGY, 2018, 56 (05)

[10] Detecting Infections Rapidly and Easily for Candidemia Trial, Part 2 (DIRECT2): A Prospective, Multicenter Study of the T2Candida Panel [J].

Clancy, Cornelius J. ;

Pappas, Peter G. ;

Vazquez, Jose ;

Judson, Marc A. ;

Kontoyiannis, Dimitrios P. ;

Thompson, George R., III ;

Garey, Kevin W. ;

Reboli, Annette ;

Greenberg, Richard N. ;

Apewokin, Senu ;

Lyon, G. Marshall, III ;

Ostrosky-Zeichner, Luis ;

Wu, Alan H. B. ;

Tobin, Ellis ;

Hong Nguyen, M. ;

Caliendo, Angela M. .

CLINICAL INFECTIOUS DISEASES, 2018, 66 (11) :1678-1686

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