Meta-analysis of Fragmented QRS as an Electrocardiographic Predictor for Arrhythmic Events in Patients with Brugada Syndrome

被引：21

作者：

Meng, Lei ^{[1
]}

Letsas, Konstantinos P. ^{[2
]}

Baranchuk, Adrian ^{[3
]}

Shao, Qingmiao ^{[1
]}

Tse, Gary ^{[4
,5
]}

Zhang, Nixiao ^{[1
]}

Zhang, Zhiwei ^{[1
]}

Hu, Dan ^{[6
,7
,8
]}

Li, Guangping ^{[1
]}

Liu, Tong ^{[1
]}

机构：

[1] Tianjin Med Univ, Hosp 2, Tianjin Key Lab Ion Mol Funct Cardiovasc Dis, Dept Cardiol,Tianjin Inst Cardiol, Tianjin, Peoples R China

[2] Evangelismos Gen Hosp Athens, Lab Cardiac Electrophysiol, Dept Cardiol 2, Athens, Greece

[3] Queens Univ, Kingston Gen Hosp, Div Cardiol, Kingston, ON, Canada

[4] Chinese Univ Hong Kong, Dept Med & Therapeut, Hong Kong, Hong Kong, Peoples R China

[5] Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Hong Kong, Hong Kong, Peoples R China

[6] Wuhan Univ, Renmin Hosp, Dept Cardiol, Wuhan, Hubei, Peoples R China

[7] Wuhan Univ, Renmin Hosp, Cardiovasc Res Inst, Wuhan, Hubei, Peoples R China

[8] Masonic Med Res Lab, Utica, NY USA

来源：

FRONTIERS IN PHYSIOLOGY | 2017年 / 8卷

关键词：

fragmented ORS; Brugada syndrome; predictor; arrhythmic events; meta-analysis; SUDDEN-DEATH; RISK MARKER; REPOLARIZATION; PREVALENCE; PROGNOSIS; MORTALITY; REGISTRY; ECG;

D O I：

10.3389/fphys.2017.00678

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Fragmented QRS (fQRS) is an electrocardiographic marker related to ventricular fibrillation NE) and sudden cardiac death (SCD) in various clinical settings. Current data regarding the prognostic significance of fQRS in Brugada syndrome (BrS) are contradictory. This meta-analysis aimed to evaluate the presence of fQRS as a risk stratification tool in BrS. Electronic databases (PubMed, EMBASE, and Cochrane Library) were searched until May 2016. Eight observational studies accumulating data on 1,637 BrS patients (mean age: 47 11 years) were included in this meta-analysis. The mean follow-up duration ranged from 21 to 96 months. fQRS was found to be an independent predictor of future arrhythmic events in BrS (RR:3.88, 95% Cl 2.26 to 6.65, p < 0.00001) with moderate heterogeneity (I-2 = 54%, P = 0.03). When analyzing VF as independent end-point, the RR for VF was 3.61, and its 95% Cl was 2.11 to 6.18, p 9 0.00001. This meta-analysis showed that BrS patients with fQRS are at high risk for future arrhythmic events. The presence of fQRS warrants prospective evaluation as valid arrhythmogenic risk marker in BrS.

引用

页数：7

共 26 条

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