Novel Perspectives towards RNA-Based Nano-Theranostic Approaches for Cancer Management

被引：36

作者：

Arshad, Rabia ^{[1
]}

Fatima, Iqra ^{[2
]}

Sargazi, Saman ^{[3
]}

Rahdar, Abbas ^{[4
]}

Karamzadeh-Jahromi, Milad ^{[5
]}

Pandey, Sadanand ^{[6
]}

Diez-Pascual, Ana M. ^{[7
]}

Bilal, Muhammad ^{[8
]}

机构：

[1] Univ Lahore, Fac Pharm, Lahore 45320, Pakistan

[2] Quaid I Azam Univ, Dept Pharm, Islamabad 45320, Pakistan

[3] Zahedan Univ Med Sci, Res Inst Cellular & Mol Sci Infect Dis, Cellular & Mol Res Ctr, Zahedan 9816743463, Iran

[4] Univ Zabol, Dept Phys, Zabol 9861335856, Iran

[5] Univ Kashan, Dept Phys, Kashan 8731751167, Iran

[6] Yeungnam Univ, Dept Chem, Coll Nat Sci, 280 Daehak Ro, Gyongsan 38541, South Korea

[7] Univ Alcala, Fac Ciencias, Dept Quim Analit Quim Fis & Ingn Quim, Ctra Madrid Barcelona,Km 33-6, Madrid 28805, Spain

[8] Huaiyin Inst Technol, Sch Life Sci & Food Engn, Huaian 223003, Peoples R China

来源：

NANOMATERIALS | 2021年 / 11卷 / 12期

关键词：

RNA nanotechnology; cancer; theranostic; nano-biosensor; MESOPOROUS SILICA NANOPARTICLES; CHITOSAN-DNA NANOPARTICLES; SIRNA DELIVERY; BIOMEDICAL APPLICATIONS; EMERGING FIELD; TARGETING RNA; IN-VITRO; NANOTECHNOLOGY; DRUGS; BIODISTRIBUTION;

D O I：

10.3390/nano11123330

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In the fight against cancer, early diagnosis is critical for effective treatment. Traditional cancer diagnostic technologies, on the other hand, have limitations that make early detection difficult. Therefore, multi-functionalized nanoparticles (NPs) and nano-biosensors have revolutionized the era of cancer diagnosis and treatment for targeted action via attaching specified and biocompatible ligands to target the tissues, which are highly over-expressed in certain types of cancers. Advancements in multi-functionalized NPs can be achieved via modifying molecular genetics to develop personalized and targeted treatments based on RNA interference. Modification in RNA therapies utilized small RNA subunits in the form of small interfering RNAs (siRNA) for overexpressing the specific genes of, most commonly, breast, colon, gastric, cervical, and hepatocellular cancer. RNA-conjugated nanomaterials appear to be the gold standard for preventing various malignant tumors through focused diagnosis and delivering to a specific tissue, resulting in cancer cells going into programmed death. The latest advances in RNA nanotechnology applications for cancer diagnosis and treatment are summarized in this review.

引用

页数：25

共 140 条

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