Biomaterials for Brain Tissue Engineering

被引：92
作者：
Pettikiriarachchi, Jerani T. S. [1 ]
Parish, Clare L. [2 ]
Shoichet, Molly S. [3 ]
Forsythe, John S. [1 ]
Nisbet, David R. [1 ,4 ]
机构：
[1] Monash Univ, Dept Mat Engn, Clayton, Vic 3800, Australia
[2] Univ Melbourne, Florey Neurosci Inst, Parkville, Vic 3010, Australia
[3] Univ Toronto, Dept Chem Engn & Appl Chem, Toronto, ON M5S 3E5, Canada
[4] Mental Hlth Res Inst Victoria, Parkville, Vic 3010, Australia
来源：
AUSTRALIAN JOURNAL OF CHEMISTRY | 2010年 / 63卷 / 08期
基金：
澳大利亚研究理事会; 英国医学研究理事会;
关键词：
NEURAL STEM-CELLS; NERVE GROWTH-FACTOR; POLY(ETHYLENE GLYCOL)/POLY(L-LYSINE) HYDROGELS; IMMOBILIZED CONCENTRATION GRADIENTS; SPINAL-CORD; NEURITE OUTGROWTH; NEUROTROPHIC FACTOR; STROMAL CELLS; THERMORESPONSIVE HYDROGEL; NANOFIBROUS SCAFFOLDS;
D O I：
10.1071/CH10159
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Neurological disorders such as traumatic brain injuries or stroke result in neuronal loss and disruption of the brain parenchyma. Current treatment strategies are limited in that they can only mitigate the degeneration process or alleviate the symptoms but do not reverse the condition. In contrast, regenerative cell-based therapies offer long-term hope for many patients. Bioactive scaffolds are likely to reinforce the success of cell replacement therapies by providing a microenvironment that facilitates the survival, proliferation, differentiation, and connectivity of transplanted and/or endogenous cells. This Review outlines various biomaterials (including hydrogels, self-assembling peptides, and electrospun nanofibres) that have been investigated for the repair of brain tissue, and discusses strategies for the immobilization of biomolecules. An overview of the potential clinical applications of such scaffolds in neurodegenerative diseases is also provided.
引用
收藏
页码：1143 / 1154
页数：12
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